Incidence of hepatocellular carcinoma in outpatients with cirrhosis in Brazil: A 10-year retrospective cohort study.

AIM

To determine the incidence of hepatocellular carcinoma (HCC) and the impact of HCC surveillance on early diagnosis and survival of cirrhotic outpatients.

METHODS

In this retrospective cohort study, cirrhotic outpatients undergoing HCC surveillance between March 2005 and March 2014 were analyzed. Exclusion criteria were HIV coinfection; previous organ transplantation; diagnosis of HCC at first consultation; missing data in the medical chart; and less than 1 year of follow-up. Surveillance was carried out every six months using ultrasound and serum alpha-fetoprotein determination. Ten-year cumulative incidence and survival were estimated through Kaplan-Meier analysis.

RESULTS

Four hundred and fifty-three patients were enrolled, of which 57.6% were male. Mean age was 55 years. Hepatitis C virus and heavy use of alcohol were the main etiologic agents of cirrhosis. HCC was diagnosed in 75 patients (16.6%), with an estimated cumulative incidence of 2.6% in the 1 year, 15.4% in the 5 year, and 28.8% in the 10 year. Median survival was estimated at 17.6 mo in HCC patients compared to 234 mo in non-HCC patients ( < 0.001). Early-stage HCC was more often detected in patients who underwent surveillance every 6 mo or less ( = 0.05). However, survival was not different between patients with early stage non-early stage tumors [HR = 0.54 (0.15-1.89), = 0.33].

CONCLUSION

HCC is a frequent complication in patients with cirrhosis and adherence to surveillance programs favors early diagnosis.