口干患者与年龄匹配的对照组相比，其唾液中皮质醇和嗜铬粒蛋白A的水平。
Salivary levels of cortisol and chromogranin A in patients with dry mouth compared with age-matched controls.
作者信息
Shigeyama Chieko, Ansai Toshihiro, Awano Shuji, Soh Inho, Yoshida Akihiro, Hamasaki Tomoko, Kakinoki Yasuaki, Tominaga Kazuhiro, Takahashi Tetsu, Takehara Tadamichi
机构信息
Division of Community Oral Health Science, Kyushu Dental College, Kitakyushu, Japan.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Dec;106(6):833-9. doi: 10.1016/j.tripleo.2008.07.005. Epub 2008 Aug 28.
OBJECTIVE
To evaluate the salivary levels of cortisol and chromogranin A (CgA) in patients with dry mouth (perceived xerostomia and hyposalivation) compared with age-matched controls.
STUDY DESIGN
We studied 174 subjects, including those with dry mouth, classified into 2 subgroups based on perceived xerostomia and salivation, and those without (control subjects). The control subjects were patients at the same hospital and healthy volunteers. Cortisol and CgA levels in stimulated whole saliva were measured using ELISA kits.
RESULTS
All subjects with dry mouth had significantly higher cortisol and CgA levels than the control subjects. The statistical associations remained significant when they were divided into the 2 subgroups, although somewhat weaker associations were observed. The influences of xerogenic drugs were found to be minimal on salivary flow rate and levels of cortisol and CgA.
CONCLUSIONS
We found significant associations between salivary cortisol and CgA levels and symptoms of oral dryness and reduced salivary flow.
目的
评估口干患者（自觉口干和唾液分泌减少）与年龄匹配的对照组相比，唾液中皮质醇和嗜铬粒蛋白A（CgA）的水平。
研究设计
我们研究了174名受试者，包括口干患者，根据自觉口干和唾液分泌情况分为2个亚组，以及无口干症状的受试者（对照组）。对照组为同一医院的患者和健康志愿者。使用酶联免疫吸附测定试剂盒测量刺激全唾液中的皮质醇和CgA水平。
结果
所有口干患者的皮质醇和CgA水平均显著高于对照组。当将他们分为2个亚组时，统计学关联仍然显著，尽管观察到的关联稍弱。发现致口干药物对唾液流速以及皮质醇和CgA水平的影响极小。
结论
我们发现唾液皮质醇和CgA水平与口腔干燥症状及唾液流速降低之间存在显著关联。
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