Develioglu Hakan, Korkmaz Saygin, Dundar Serkan, Schlagenhauf Ulrich
Sivas Cumhuriyet University, Faculty of Dentisty, Department of Periodontology, Sivas, Turkey.
Firat University, Faculty of Dentistry, Department of Periodontology, Elazig, Turkey.
J Oral Biol Craniofac Res. 2020 Oct-Dec;10(4):514-518. doi: 10.1016/j.jobcr.2020.07.020. Epub 2020 Aug 12.
In this study, we aimed to determine the salivary levels of cortisol, α-amylase, β-endorphin, and chromogranin (CgA) in saliva and to investigate their relationship with periodontitis.
Thirty-seven female and 43 male periodontitis patients who presented to the Periodontology Department of the XXX University Faculty of Dentistry participated in the study. The individuals were divided into three groups: mild, moderate, or severe chronic periodontitis. Plaque index (PI), gingival index (GI), clinical attachment loss (CAL), and probing depth (PD) measurements were recorded for all the participants. All participants underwent the State-Trait Anxiety Inventory test (STAI 1 and 2). Between 09:00 and 11:00 a.m., saliva samples from the participants were collected into tubes within an average of five minutes.
Higher cortisol measurements were detected in the saliva samples of participants with severe chronic periodontitis than in those who had mild chronic periodontitis (P < 0.05). There were statistically significant age differences among patients with mild-moderate, moderate-severe, and mild chronic periodontitis, the severity of the disease increasing with age (P < 0.05). There was also a positive correlation between STAI 1 stress scores and cortisol levels. Similarly, there was a positive correlation between CAL and cortisol levels (P < 0.05). However, a significant difference was found among groups only in terms of salivary cortisol levels (P < 0.05).
Within the limitations of this study, there was found to be a relationship between saliva cortisol levels and periodontitis and between salivary cortisol levels and stress.
在本研究中，我们旨在测定唾液中皮质醇、α-淀粉酶、β-内啡肽和嗜铬粒蛋白（CgA）的水平，并研究它们与牙周炎的关系。
XXX大学牙科学院牙周病科的37名女性和43名男性牙周炎患者参与了本研究。这些个体被分为三组：轻度、中度或重度慢性牙周炎。记录了所有参与者的菌斑指数（PI）、牙龈指数（GI）、临床附着丧失（CAL）和探诊深度（PD）测量值。所有参与者均接受了状态-特质焦虑量表测试（STAI 1和2）。上午9点至11点之间，参与者的唾液样本在平均五分钟内被收集到试管中。
重度慢性牙周炎参与者的唾液样本中检测到的皮质醇测量值高于轻度慢性牙周炎参与者（P < 0.05）。轻度-中度、中度-重度和轻度慢性牙周炎患者之间存在统计学上显著的年龄差异，疾病严重程度随年龄增加（P < 0.05）。STAI 1应激评分与皮质醇水平之间也存在正相关。同样，CAL与皮质醇水平之间存在正相关（P < 0.05）。然而，仅在唾液皮质醇水平方面，各组之间存在显著差异（P < 0.05）。
在本研究的局限性内，发现唾液皮质醇水平与牙周炎之间以及唾液皮质醇水平与应激之间存在关系。
