Department of Oral Medicine/Dental Research Center, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Gerodontology. 2012 Mar;29(1):43-7. doi: 10.1111/j.1741-2358.2010.00403.x. Epub 2010 Jul 15.
To evaluate the relationship of stimulated whole saliva cortisol level with the severity of a feeling of dry mouth (DM) in menopausal women.
A feel of DM is a major complaint for many elderly individuals and strongly associated with the menopause. The exact mechanisms that mediate sensation of DM in menopausal women have not been firmly established.
A case-control study was carried out on 104 selected menopausal women with/without a feeling of DM, conducted at the Clinic of Oral Medicine, Tehran University of Medical Sciences. Xerostomia Inventory (XI) score was used as an index of DM severity. Stimulated whole saliva cortisol concentration (stimulated by chewing standard-sized paraffin for 60 s) was measured by ELISA. Statistical analysis by Student's t-test and Spearman correlation was used.
The mean cortisol concentration of saliva, but not saliva cortisol output, was significantly higher in the cases than in the controls. There was significant positive correlation between XI score and concentration (r = 0.357, p = 0.000) or output (r = 0.223, p = 0.017) of stimulated whole saliva cortisol.
It appears that stimulated whole saliva cortisol is high in menopausal women with a feeling of DM.
评估刺激全唾液皮质醇水平与绝经后妇女口干感严重程度的关系。
口干感是许多老年人的主要抱怨，与绝经密切相关。介导绝经后妇女口干感的确切机制尚未确定。
在德黑兰医科大学口腔医学诊所进行了一项病例对照研究，纳入了 104 名有/无口干感的绝经后妇女。口干感严重程度的指标为 Xerostomia Inventory (XI) 评分。采用 ELISA 法测定刺激全唾液皮质醇浓度（咀嚼标准大小的石蜡 60 秒刺激）。采用 Student's t 检验和 Spearman 相关分析进行统计学分析。
病例组唾液皮质醇浓度的平均值较高，但唾液皮质醇的分泌量没有差异。XI 评分与刺激全唾液皮质醇的浓度（r=0.357，p=0.000）或分泌量（r=0.223，p=0.017）呈显著正相关。
绝经后有口干感的妇女刺激全唾液皮质醇水平较高。
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