Otsubo Yoko, Yamamato Masayuki
Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Hongo, Tokyo, Japan.
Crit Rev Biochem Mol Biol. 2008 Jul-Aug;43(4):277-83. doi: 10.1080/10409230802254911.
Fission yeast has two TOR kinases, Tor1 and Tor2. Recent studies have indicated that this microbe has a TSC/Rheb/TOR pathway like higher eukaryotes. Two TOR complexes, namely TORC1 and TORC2, have been identified in this yeast, as in budding yeast and mammals. Fission yeast TORC1, which contains Tor2, and TORC2, which contains Tor1, apparently have opposite functions with regard to the promotion of G1 arrest and sexual development. Rapamycin does not inhibit growth of wild-type fission yeast cells, unlike other eukaryotic cells, but precise analyses have revealed that rapamycin affects certain cellular functions involving TOR in this yeast. It appears that fission yeast has a potential to be an ideal model system to investigate the TOR signaling pathways.
裂殖酵母有两种TOR激酶，Tor1和Tor2。最近的研究表明，这种微生物具有类似于高等真核生物的TSC/Rheb/TOR途径。与芽殖酵母和哺乳动物一样，在这种酵母中已鉴定出两种TOR复合物，即TORC1和TORC2。含有Tor2的裂殖酵母TORC1和含有Tor1的TORC2在促进G1期停滞和有性发育方面显然具有相反的功能。与其他真核细胞不同，雷帕霉素不抑制野生型裂殖酵母细胞的生长，但精确分析表明雷帕霉素会影响这种酵母中涉及TOR的某些细胞功能。看来裂殖酵母有潜力成为研究TOR信号通路的理想模型系统。
