Sidani Charif A, Ballourah Walid, El Dassouki Mohamad, Muwakkit Samar, Dabbous Ibrahim, Dahoui Hanan, Al-Kutoubi Aghiad, Abboud Miguel R
Department of Radiology, American University of Beirut Medical Center, Beirut, Lebanon.
Am J Hematol. 2008 Oct;83(10):818-20. doi: 10.1002/ajh.21261.
A 21-year-old man with homozygous sickle cell disease maintained on hydroxyurea for 1 year developed thrombosis of the superior sagittal, right transverse, and right sigmoid dural sinuses with a large venous infarct. He was successfully treated with endovascular thrombolysis. Investigation did not reveal any inherited or acquired hypercoagulable state. This patient however had consistently elevated hemoglobin levels both at the time of the initial event and on follow up. One year later he developed symptomatic avascular necrosis of the right hip. High hemoglobin levels resulting from hydroxyurea therapy may have contributed to development of complications in this patient.
一名21岁的纯合子镰状细胞病男性患者，服用羟基脲维持治疗1年，发生了上矢状窦、右侧横窦和右侧乙状窦硬膜窦血栓形成，并伴有大面积静脉梗死。他接受血管内溶栓治疗成功。检查未发现任何遗传性或获得性高凝状态。然而，该患者在初始事件发生时及随访期间血红蛋白水平持续升高。1年后，他出现了右侧髋关节有症状的缺血性坏死。羟基脲治疗导致的高血红蛋白水平可能促使该患者出现并发症。
