McLaughlin E T, Bethea L H, Wittig H J
Ann Allergy. 1982 Oct;49(4):191-5.
Sixteen children with asthma took part in a double-blind, crossover comparison study of single doses of fenoterol (2.5, 5.0 and 7.5 mg), ephedrine (24 mg) and placebo. Spirometry was performed before drug administration and then hourly for six hours thereafter. Mean values were plotted for six hours after dur administration. All active drugs were superior to placebo. The greatest differences were in FEF25-75 spirometry levels although the differences for FEV1 did reach statistical significance. The 7.5 mg dose of fenoterol was superior to all other active drug categories. Although effects of tremor and nausea were minimal, significant tachycardia and palpitations were noted with the 5.0 mg and 7.5 mg doses of fenoterol.
16名哮喘患儿参与了一项双盲交叉对照研究，该研究对比了单次剂量的非诺特罗（2.5毫克、5.0毫克和7.5毫克）、麻黄碱（24毫克）及安慰剂的效果。在给药前进行了肺活量测定，之后每小时测定一次，共持续6小时。给药后6小时绘制了平均值曲线。所有活性药物均优于安慰剂。最大差异体现在用力呼气流量25%-75%的肺活量测定水平上，尽管第一秒用力呼气量（FEV1）的差异也达到了统计学显著性。7.5毫克剂量的非诺特罗优于所有其他活性药物类别。尽管震颤和恶心的影响极小，但5.0毫克和7.5毫克剂量的非诺特罗出现了显著的心动过速和心悸。
