Zaaimi Boubker, Grebe Reinhard, Wallois Fabrice
GRAMFC, Faculté de Médecine, Amiens, France.
Auton Neurosci. 2008 Dec 5;143(1-2):20-6. doi: 10.1016/j.autneu.2008.07.002. Epub 2008 Aug 30.
To develop an animal model of the effects of vagus nerve stimulation (VNS) on heart rate and respiration in studies of seizure treatment.
Nine rats implanted with ECG, EMG, and VNS electrodes and pulse generator were stimulated with 81 different sets of parameters while they slept in a plethysmographic box.
From cardiorespiratory effects of VNS, an index (alpha) was found to distinguish between weak and strong VNS doses. Weak VNS dose induced an increase in respiratory frequency and no significant change in heart rate. The effect of VNS on respiration, similar to that observed in children, can be divided into 3 phases. Strong VNS dose induced a decrease in respiratory frequency concomitant with a decrease in heart rate. Increasing the intensity of the VNS induced a proportional increase in the maximal inspiratory strength.
Various VNS parameter settings induce different and concomitant cardiorespiratory variations in conscious sleeping rats. These effects correlate with the intensity of the VNS parameters. Understanding the effects of the intensity of VNS parameters may allow for further optimization of VNS parameters in patients receiving VNS.
在癫痫治疗研究中建立一种迷走神经刺激（VNS）对心率和呼吸影响的动物模型。
9只植入了心电图、肌电图和VNS电极以及脉冲发生器的大鼠在体积描记箱中睡眠时，用81组不同参数进行刺激。
从VNS的心肺效应中，发现一个指数（α）可区分弱和强VNS剂量。弱VNS剂量导致呼吸频率增加且心率无显著变化。VNS对呼吸的影响，类似于在儿童中观察到的情况，可分为3个阶段。强VNS剂量导致呼吸频率降低并伴有心率降低。增加VNS强度会导致最大吸气力量成比例增加。
在清醒睡眠的大鼠中，各种VNS参数设置会引起不同且伴随的心肺变化。这些效应与VNS参数的强度相关。了解VNS参数强度的影响可能有助于进一步优化接受VNS治疗患者的VNS参数。
