Zhou Li, Zhang Xiaomin, He Mei'an, Cheng Longxian, Chen Ying, Hu Frank B, Wu Tangchun
Institute of Occupational Medicine, School of Public Health, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
Arterioscler Thromb Vasc Biol. 2008 Nov;28(11):2085-9. doi: 10.1161/ATVBAHA.108.176065. Epub 2008 Aug 28.
We aimed to determine whether the single nucleotide polymorphisms (SNPs) on chromosome 9p21 were associated with coronary heart disease (CHD) in a Chinese Han population.
We determined the genotypes of rs2383206 and rs2383207 on chromosome 9p21 in 1360 CHD patients and 1360 age- and sex-frequency-matched controls from an unrelated Chinese Han population. GG genotypes in rs2383207 occurred more frequently in CHD patients compared to controls, and the odds ratio (OR) was 1.52 (95% CI 1.13 to 2.04), after adjusting for conventional risk factors. In stratified analysis, the risk associated with the GG genotype of the two SNPs was stronger in subjects who were males, less than 60 years old, overweight, and smokers. The SNP rs2383207 had significant interactions with gender and smoking (P=0.018 and 0.037, respectively). The risk allele G of rs2383207 plus family history of CHD had a cumulative association with CHD (P for trend, 1.0x10(-6)); the OR for CHD was 4.59 (95% CI 2.52 to 8.37) for those with all the risk factors as compared with subjects without any of the factors.
The SNP rs2383207 on chromosome 9p21 is significantly associated with CHD in Chinese. This SNP combined with family history has a cumulative association with CHD.
我们旨在确定9号染色体p21区域的单核苷酸多态性（SNP）是否与中国汉族人群的冠心病（CHD）相关。
我们对1360例冠心病患者以及1360例来自非亲缘关系中国汉族人群、年龄和性别频率匹配的对照者，测定了9号染色体p21区域rs2383206和rs2383207的基因型。与对照组相比，rs2383207的GG基因型在冠心病患者中出现的频率更高，在调整传统危险因素后，比值比（OR）为1.52（95%可信区间1.13至2.04）。在分层分析中，两个SNP的GG基因型相关风险在男性、年龄小于60岁、超重和吸烟者中更强。SNP rs2383207与性别和吸烟存在显著交互作用（P分别为0.018和0.037）。rs2383207的风险等位基因G加上冠心病家族史与冠心病存在累积关联（趋势P值为1.0×10⁻⁶）；与无任何危险因素的受试者相比，具有所有危险因素的受试者患冠心病的OR为4.59（95%可信区间2.52至8.37）。
9号染色体p21区域的SNP rs2383207与中国人群的冠心病显著相关。该SNP与家族史相结合与冠心病存在累积关联。
