Braedt G, Gallant J
J Bacteriol. 1977 Jan;129(1):564-6. doi: 10.1128/jb.129.1.564-566.1977.
The presence of a relA mutant allele affects the kinetics of cyclic adenosine 3',5'-monophosphate accumulation during downshift from glucose to succinate. The nucleotide accumulates at the normal rate early in the downshift transition but continues to accumulate for a longer time in the relA mutant, leading to a two- to threefold excess by the end of the diauxic lag. Evidence is presented that this effect occurs independently of the accumulation of ppGpp.
relA突变等位基因的存在会影响从葡萄糖向琥珀酸转换过程中3',5'-环磷酸腺苷积累的动力学。在转换初期,核苷酸以正常速率积累,但在relA突变体中会持续积累更长时间,导致在二次生长停滞结束时积累量多出两到三倍。有证据表明,这种效应的发生与ppGpp的积累无关。