Pastan I, Perlman R
Science. 1970 Jul 24;169(3943):339-44. doi: 10.1126/science.169.3943.339.
Both cyclic AMP and a specific inducer acting in concert are required for the synthesis of many inducible enzymes in E. coli. Little enzyme is made in the absence of either. In contrast to the specific inducers which stimulate the synthesis only of the proteins required for their metabolism, cyclic AMP controls the synthesis of many proteins. Glucose and certain other carbohydrates decrease the differential rate of synthesis of inducible enzymes by lowering cyclic AMP concentrations. In the lac operon, cyclic AMP acts at the promoter site to facilitate initiation of transcription. This action requires another protein, the cyclic AMP receptor protein. The nucleotide stimulates tryptophanase synthesis at a translational level. The action of cyclic AMP in E. coli may serve as a model to understand its action on transcriptional and translational processes in eukaryotes.
环腺苷酸（cAMP）和一种协同作用的特异性诱导剂对于大肠杆菌中许多诱导酶的合成都是必需的。若缺少其中任何一种，酶的合成量都很少。与仅刺激其代谢所需蛋白质合成的特异性诱导剂不同，环腺苷酸控制着许多蛋白质的合成。葡萄糖和某些其他碳水化合物通过降低环腺苷酸浓度来降低诱导酶的差异合成速率。在乳糖操纵子中，环腺苷酸作用于启动子位点以促进转录起始。此作用需要另一种蛋白质，即环腺苷酸受体蛋白。该核苷酸在翻译水平上刺激色氨酸酶的合成。环腺苷酸在大肠杆菌中的作用可作为理解其对真核生物转录和翻译过程作用的模型。
