Kouriefs Chryssanthos, Loizides Sofronis, Mufti Gulzar
Urology Department, Medway Maritime Hospital, Gillingham, UK.
Urol Int. 2008;81(2):125-8. doi: 10.1159/000144048. Epub 2008 Aug 29.
This study aims to review and assess the safety of carrying out transurethral resection of prostate (TURP) and transurethral resection of bladder tumour (TURBT) simultaneously, in men who require TURP for bladder outflow obstruction and are incidentally found to have a transitional cell carcinoma of the bladder.
A detailed Medline search between 1966 and 2005 identified only five published papers in the English literature addressing this subject. These were retrospective studies of small numbers and were analysed together in order to quantify the risk of bladder cancer recurrence that could be attributed to TURP. The anatomical area of interest for tumour recurrence was hence the bladder neck and prostatic urethra.
424 patients had simultaneous TURBT and TURP, whereas 350 had TURBT alone. The rate of recurrence of bladder tumour in these two groups of patients was 58 and 63%, respectively. The recurrence rate at the bladder neck and prostatic urethra was equally comparable. Tumour grade and multiplicity do not appear to influence the tumour recurrence rate when TURP is carried out at the same time as TURBT.
There is paucity of clinical evidence to support the theoretical risk of tumour cell implantation at the bladder neck and prostatic urethra when TURP is carried out at the time of TURBT.
本研究旨在回顾和评估在因膀胱出口梗阻需要行经尿道前列腺切除术（TURP）且偶然发现患有膀胱移行细胞癌的男性患者中，同时进行经尿道前列腺切除术（TURP）和经尿道膀胱肿瘤切除术（TURBT）的安全性。
对1966年至2005年间的Medline进行详细检索，仅在英文文献中发现五篇已发表的关于该主题的论文。这些均为小样本回顾性研究，对其进行综合分析以量化可归因于TURP的膀胱癌复发风险。因此，肿瘤复发的感兴趣解剖区域为膀胱颈和前列腺尿道。
424例患者同时进行了TURBT和TURP，而350例仅进行了TURBT。这两组患者的膀胱肿瘤复发率分别为58%和63%。膀胱颈和前列腺尿道的复发率相当。当TURP与TURBT同时进行时，肿瘤分级和多灶性似乎不影响肿瘤复发率。
缺乏临床证据支持在TURBT时进行TURP会导致肿瘤细胞种植于膀胱颈和前列腺尿道的理论风险。
