Department of Pediatrics, University of Kentucky College of Medicine J410 Kentucky Clinic, 740 South Limestone Street, Lexington, KY 40536, USA.
Heart Fail Rev. 2009 Sep;14(3):171-82. doi: 10.1007/s10741-008-9102-1. Epub 2008 Aug 29.
Insomnia is highly prevalent in patients with chronic disease including chronic heart failure (CHF) and is a significant contributing factor to fatigue and poor quality of life. The pathophysiology of CHF often leads to fatigue, due to nocturnal symptoms causing sleep disruption, including cough, orthopnea, paroxysmal nocturnal dyspnea, and nocturia. Inadequate cardiac function may lead to hypoxemia or poor perfusion of the cerebrum, skeletal muscle, or visceral body organs, which result in organ dysfunction or failure and may contribute to fatigue. Sleep disturbances negatively affect all dimensions of quality of life and is related to increased risk of comorbidities, including depression. This article reviews insomnia in CHF, cardiac medication side-effects related to sleep disturbances, and treatment options.
失眠在患有慢性疾病的患者中非常普遍，包括慢性心力衰竭（CHF），是导致疲劳和生活质量下降的重要因素。CHF 的病理生理学常常导致疲劳，因为夜间症状会导致睡眠中断，包括咳嗽、端坐呼吸、阵发性夜间呼吸困难和夜尿症。心功能不全可导致缺氧或大脑、骨骼肌或内脏器官的灌注不良，从而导致器官功能障碍或衰竭，并可能导致疲劳。睡眠障碍会对生活质量的所有方面产生负面影响，并与并发症风险增加相关，包括抑郁。本文综述了 CHF 中的失眠、与睡眠障碍相关的心脏药物副作用以及治疗选择。
