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在含有人类I型嗜T细胞病毒tax基因的转基因小鼠中神经生长因子的反式激活

trans activation of nerve growth factor in transgenic mice containing the human T-cell lymphotropic virus type I tax gene.

作者信息

Green J E

机构信息

Laboratory of Molecular Oncology, National Cancer Institute, Frederick, Maryland 21702-1201.

出版信息

Mol Cell Biol. 1991 Sep;11(9):4635-41. doi: 10.1128/mcb.11.9.4635-4641.1991.

DOI:10.1128/mcb.11.9.4635-4641.1991
PMID:1875943
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC361349/
Abstract

Three lines of transgenic mice containing the human T-cell lymphotropic virus type I (HTLV-I) tax gene develop neurofibromas composed of perineural fibroblasts (S. H. Hinrichs, M. Nerenberg, R. K. Reynolds, G. Khoury, and G. Jay, Science 237:1340-1343, 1987; M. Nerenberg, S. H. Hinrichs, R. K. Reynolds, G. Khoury, and G. Jay, Science 237:1324-1327, 1987). Tumors and tumor cell lines derived from these mice produce neurite outgrowth from PC-12 cells and nerve growth factor (NGF), as determined by RNA (Northern) blot analysis and enzyme-linked immunosorbent assays. In vitro cotransfection studies demonstrate that Tax is able to trans activate the NGF promoter in NIH 3T3 fibroblast cells. The major cis-acting tax-responsive element in the NGF promoter (AGGGTGTGACGA) has 92% homology with a tax-responsive element contained within the 21-bp repeats of the HTLV-I long terminal repeat. The receptor for NGF is also expressed in the transgenic tumor cells, suggesting that Tax may activate an autocrine mechanism through the upregulation of NGF.

摘要

携带人类I型嗜T细胞病毒（HTLV-I）tax基因的三系转基因小鼠会发展出由神经周成纤维细胞组成的神经纤维瘤（S.H.欣里希斯、M.内伦贝格、R.K.雷诺兹、G.库里和G.杰伊，《科学》237:1340 - 1343，1987；M.内伦贝格、S.H.欣里希斯、R.K.雷诺兹、G.库里和G.杰伊，《科学》237:1324 - 1327，1987）。通过RNA（Northern）印迹分析和酶联免疫吸附测定确定，源自这些小鼠的肿瘤和肿瘤细胞系能使PC - 12细胞产生神经突生长并分泌神经生长因子（NGF）。体外共转染研究表明，Tax能够在NIH 3T3成纤维细胞中转激活NGF启动子。NGF启动子中的主要顺式作用tax反应元件（AGGGTGTGACGA）与HTLV - I长末端重复序列21 bp重复序列中包含的一个tax反应元件具有92%的同源性。NGF受体也在转基因肿瘤细胞中表达，这表明Tax可能通过上调NGF激活自分泌机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a07b/361349/d55a3033295d/molcellb00033-0363-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a07b/361349/0b365f24f123/molcellb00033-0361-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a07b/361349/01380164fa33/molcellb00033-0362-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a07b/361349/608f32842e4b/molcellb00033-0363-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a07b/361349/d55a3033295d/molcellb00033-0363-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a07b/361349/0b365f24f123/molcellb00033-0361-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a07b/361349/01380164fa33/molcellb00033-0362-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a07b/361349/608f32842e4b/molcellb00033-0363-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a07b/361349/d55a3033295d/molcellb00033-0363-b.jpg

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本文引用的文献

1
Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera.成人T细胞白血病：一种成人T细胞白血病细胞系中的抗原及人血清中该抗原抗体的检测
Proc Natl Acad Sci U S A. 1981 Oct;78(10):6476-80. doi: 10.1073/pnas.78.10.6476.
2
Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease.从成人T细胞白血病细胞系中分离和鉴定逆转录病毒及其在该疾病中的意义。
Proc Natl Acad Sci U S A. 1982 Mar;79(6):2031-5. doi: 10.1073/pnas.79.6.2031.
3
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.
J Virol. 1993 Jul;67(7):4436-41. doi: 10.1128/JVI.67.7.4436-4441.1993.
4
Differential expression of Rel family members in human T-cell leukemia virus type I-infected cells: transcriptional activation of c-rel by Tax protein.Rel家族成员在人I型T细胞白血病病毒感染细胞中的差异表达：Tax蛋白对c-rel的转录激活
J Virol. 1993 Jul;67(7):4205-13. doi: 10.1128/JVI.67.7.4205-4213.1993.
5
Overgrowth of human synovial cells driven by the human T cell leukemia virus type I tax gene.由I型人类T细胞白血病病毒tax基因驱动的人类滑膜细胞过度生长。
J Clin Invest. 1993 Jul;92(1):186-93. doi: 10.1172/JCI116548.
6
Functional and biochemical interaction of the HTLV-I Tax1 transactivator with TBP.人嗜T淋巴细胞病毒I型（HTLV-I）反式激活因子Tax1与TATA结合蛋白（TBP）的功能及生化相互作用
EMBO J. 1993 Nov;12(11):4269-78. doi: 10.1002/j.1460-2075.1993.tb06111.x.
7
Tax induces nuclear translocation of NF-kappa B through dissociation of cytoplasmic complexes containing p105 or p100 but does not induce degradation of I kappa B alpha/MAD3.Tax通过解离含有p105或p100的细胞质复合物诱导NF-κB的核转位，但不诱导IκBα/MAD3的降解。
J Virol. 1994 Dec;68(12):8035-44. doi: 10.1128/JVI.68.12.8035-8044.1994.
8
Augmentation of c-fos and c-jun expression in transgenic mice carrying the human T-cell leukemia virus type-I tax gene.携带人I型T细胞白血病病毒tax基因的转基因小鼠中c-fos和c-jun表达的增强。
Virus Genes. 1995 Jan;9(2):161-70. doi: 10.1007/BF01702659.
9
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Am J Pathol. 1992 Jun;140(6):1401-10.
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Mol Cell Biol. 1982 Sep;2(9):1044-51. doi: 10.1128/mcb.2.9.1044-1051.1982.
4
Natural antibodies to human retrovirus HTLV in a cluster of Japanese patients with adult T cell leukemia.一群日本成人T细胞白血病患者体内针对人类逆转录病毒HTLV的天然抗体。
Science. 1982 Feb 19;215(4535):975-8. doi: 10.1126/science.6760397.
5
Expression of the beta-nerve growth factor gene correlates with the density of sympathetic innervation in effector organs.β-神经生长因子基因的表达与效应器官中交感神经支配的密度相关。
Proc Natl Acad Sci U S A. 1984 Dec;81(24):7951-5. doi: 10.1073/pnas.81.24.7951.
6
Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor.编码小鼠神经生长因子前体的cDNA的分离及核苷酸序列
Nature. 1983 Apr 7;302(5908):538-40. doi: 10.1038/302538a0.
7
Trans-acting transcriptional activation of the long terminal repeat of human T lymphotropic viruses in infected cells.人嗜T淋巴细胞病毒长末端重复序列在受感染细胞中的反式作用转录激活
Science. 1984 Jul 27;225(4660):381-5. doi: 10.1126/science.6330891.
8
Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma.从一名皮肤T细胞淋巴瘤患者的新鲜淋巴细胞和培养淋巴细胞中检测并分离C型逆转录病毒颗粒。
Proc Natl Acad Sci U S A. 1980 Dec;77(12):7415-9. doi: 10.1073/pnas.77.12.7415.
9
A new technique for the assay of infectivity of human adenovirus 5 DNA.一种检测人腺病毒5型DNA感染性的新技术。
Virology. 1973 Apr;52(2):456-67. doi: 10.1016/0042-6822(73)90341-3.
10
Autocrine growth factors and cancer.自分泌生长因子与癌症。
Nature. 1985;313(6005):745-7. doi: 10.1038/313745a0.