Sodroski J G, Rosen C A, Haseltine W A
Science. 1984 Jul 27;225(4660):381-5. doi: 10.1126/science.6330891.
The transcription initiation signals for retroviruses lie within the long terminal repeat (LTR) sequences that flank the integrated provirus. Two subtypes of human T lymphotropic virus (HTLV) are associated with different disease phenotypes. In this article it is shown that marked differences exist in the ability of LTR sequences of these subtypes to function as transcriptional elements in differentiated cell types. It is also shown that trans-acting regulatory factors present in HTLV-infected cells stimulate gene expression directed by these LTR sequences in a type-specific manner. These results have implications for understanding the diverse biological effects of HTLV infection.
逆转录病毒的转录起始信号位于整合原病毒两侧的长末端重复序列（LTR）内。人类嗜T淋巴细胞病毒（HTLV）的两个亚型与不同的疾病表型相关。本文表明，这些亚型的LTR序列在分化细胞类型中作为转录元件发挥功能的能力存在显著差异。还表明，HTLV感染细胞中存在的反式作用调节因子以类型特异性方式刺激由这些LTR序列指导的基因表达。这些结果对于理解HTLV感染的多种生物学效应具有重要意义。
