Okeke C N, Gugnani H C, Onuigbo W I
Department of Microbiology, University of Nigeria, Nsukka.
Mycopathologia. 1991 May;114(2):65-70. doi: 10.1007/BF00436423.
The potential pathogenicity of one isolate each of Cladosporium tennuisimum, Phaeoisaria clematidis and Ramichloridium subulatum for mice was investigated by intravenous, intraperitoneal and subcutaneous routes of inoculation with saline and mucin suspensions of the organisms. No mice died during the experimental period. Dark nodular lesions were formed in the liver, spleen, kidneys, intestine, stomach, omentum and diaphragm after inoculation through the intravenous and intraperitoneal routes. Gross lesions were produced in the lungs of one mouse inoculated intravenously with R. subulatum. Localised nodular lesions were formed in the subcutis following the subcutaneous route. Tissue response was characterised by granulomatous inflammatory reaction. Fungal elements were confined within the granulomata. Though the fungi showed limited pathogenic potential, they may represent a hazard under conditions of compromised host immunity.
通过静脉内、腹腔内和皮下途径，用细弱枝孢、铁线莲拟茎点霉和细梗柱孢的生理盐水和粘蛋白悬液对小鼠进行接种，研究了这三种真菌各一个分离株对小鼠的潜在致病性。实验期间无小鼠死亡。经静脉内和腹腔内途径接种后，在肝脏、脾脏、肾脏、肠道、胃、网膜和膈肌中形成了深色结节性病变。静脉内接种细梗柱孢的一只小鼠肺部出现肉眼可见的病变。皮下途径接种后，在皮下形成局限性结节性病变。组织反应的特征为肉芽肿性炎症反应。真菌成分局限于肉芽肿内。虽然这些真菌显示出有限的致病潜力，但在宿主免疫功能受损的情况下，它们可能构成一种危害。
