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膝曲弯孢霉动物模型及其与人类疾病的关系。

An animal model of Curvularia geniculata and its relationship with human disease.

作者信息

Alture-Werber E, Edberg S C

出版信息

Mycopathologia. 1985 Feb;89(2):69-73. doi: 10.1007/BF00431472.

DOI:10.1007/BF00431472
PMID:4039412
Abstract

The conidiospore of Curvularia geniculata was observed in the bronchial washings of a patient who subsequently developed pulmonary aspergillosis. Curvularia geniculata was grown in culture and used in experiments in mice to explore its possible role as a disease causing agent. The fungus, after intraperitoneal injection, produced granulomas in the liver and spleen. Studies on the pathogenicity of this fungus in mice produced similar lesions to those observed in the human case. A comparison of the lesions in the patient's lung and in the animal experimental model is presented.

摘要

在一名随后发展为肺曲霉病的患者的支气管灌洗物中观察到膝曲弯孢霉的分生孢子。将膝曲弯孢霉进行培养,并用于小鼠实验,以探究其作为致病因子的可能作用。该真菌经腹腔注射后,在肝脏和脾脏中产生肉芽肿。对这种真菌在小鼠中的致病性研究产生了与人类病例中观察到的类似病变。本文对患者肺部病变与动物实验模型中的病变进行了比较。

相似文献

1
An animal model of Curvularia geniculata and its relationship with human disease.膝曲弯孢霉动物模型及其与人类疾病的关系。
Mycopathologia. 1985 Feb;89(2):69-73. doi: 10.1007/BF00431472.
2
Lesions experimentally produced by fungi implicated in extrinsic allergic alveolitis.由与外源性过敏性肺泡炎相关的真菌实验性产生的病变。
J Hyg (Lond). 1974 Dec;73(3):369-74. doi: 10.1017/s0022172400042716.
3
Unusual aspects of allergic bronchopulmonary fungal disease: report of two cases due to Curvularia organisms associated with allergic fungal sinusitis.变应性支气管肺真菌病的不寻常方面:两例由弯孢属真菌引起并伴有变应性真菌性鼻窦炎的病例报告
Hum Pathol. 1991 Dec;22(12):1240-8. doi: 10.1016/0046-8177(91)90106-y.
4
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Mycopathologia. 1975 Nov 21;56(3):143-8. doi: 10.1007/BF02093312.
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本文引用的文献

1
CURVULARIA GENICULATA, A CAUSE OF MYCOTIC KERATITIS.膝曲弯孢霉,一种真菌性角膜炎的病因。
J Med Assoc State Ala. 1964 Feb;33:234-6.
2
A CASE OF MYCOTIC KERATITIS CAUSED BY CURVULARIA GENICULATA.弯孢霉引起的霉菌性角膜炎一例。
Arch Ophthalmol. 1964 Apr;71:456-8. doi: 10.1001/archopht.1964.00970010472003.
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Mycotic keratitis.
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[Identification of the agents of maduromycoses of Senegal and Mauritania. Description of a new species].
Bull Soc Pathol Exot Filiales. 1959 Jul-Aug;52:448-77.
5
Maduromycotic mycetomas in animals; Curvularia geniculata as an etiologic agent.动物中的马杜拉真菌性足菌肿;膝曲弯孢霉作为病原体
Am J Pathol. 1957 May-Jun;33(3):411-27.
6
Mycetoma in a dog.犬足菌肿
J Am Vet Med Assoc. 1955 Nov;127(944):444-5.
7
Curvularia lunata in experimental phaeohyphomycosis.新月弯孢霉与实验性暗色丝孢霉病
Mycopathologia. 1981 Aug 7;75(2):81-8. doi: 10.1007/BF00505782.
8
Mycetoma in a dog.
J Am Vet Med Assoc. 1967 Aug 15;151(4):442-51.
9
Keratomycosis due to Curvularia lunata.新月弯孢霉引起的角膜真菌病。
Arch Ophthalmol. 1970 Nov;84(5):694-6. doi: 10.1001/archopht.1970.00990040696026.
10
Curvularia endocarditis following cardiac surgery.心脏手术后的弯孢霉性心内膜炎
Am J Clin Pathol. 1971 Oct;56(4):466-70. doi: 10.1093/ajcp/56.4.466.