Runyon Kelly, Bui Tung, Mazanek Sarah, Hartle Alec, Marschalko Katie, Howe William Matthew
School of Neuroscience at Virginia Tech, Blacksburg, VA, United States.
Front Mol Neurosci. 2024 Aug 29;17:1429316. doi: 10.3389/fnmol.2024.1429316. eCollection 2024.
Attention and reward are functions that are critical for the control of behavior, and massive multi-region neural systems have evolved to support the discrete computations associated with each. Previous research has also identified that attention and reward interact, though our understanding of the neural mechanisms that mediate this interplay is incomplete. Here, we review the basic neuroanatomy of attention, reward, and cholinergic systems. We then examine specific contexts in which attention and reward computations interact. Building on this work, we propose two discrete neural circuits whereby acetylcholine, released from cell groups located in different parts of the brain, mediates the impact of stimulus-reward associations as well as motivation on attentional control. We conclude by examining these circuits as a potential shared loci of dysfunction across diseases states associated with deficits in attention and reward.
注意力和奖赏是对行为控制至关重要的功能，大量的多区域神经系统已经进化以支持与它们各自相关的离散计算。先前的研究也已经确定注意力和奖赏相互作用，尽管我们对介导这种相互作用的神经机制的理解并不完整。在这里，我们回顾注意力、奖赏和胆碱能系统的基本神经解剖学。然后我们研究注意力和奖赏计算相互作用的特定情境。在此基础上，我们提出两个离散的神经回路，位于大脑不同部位的细胞群释放的乙酰胆碱通过这两个回路介导刺激-奖赏关联以及动机对注意力控制的影响。我们通过将这些回路视为与注意力和奖赏缺陷相关的疾病状态下功能障碍的潜在共同位点来进行总结。
