通过光学相干断层扫描测量晶状体厚度随年龄和调节的变化
Lens thickness with age and accommodation by optical coherence tomography.
作者信息
Richdale Kathryn, Bullimore Mark A, Zadnik Karla
机构信息
The Ohio State University College of Optometry, 338 West 10th Avenue, Columbus, OH 43210, USA.
出版信息
Ophthalmic Physiol Opt. 2008 Sep;28(5):441-7. doi: 10.1111/j.1475-1313.2008.00594.x.
PURPOSE
To utilize time-domain optical coherence tomography (OCT) to measure changes in the crystalline lens with age and accommodation.
METHODS
A cross-sectional study of pre-presbyopic and presbyopic subjects was conducted. Amplitude of accommodation was measured with the push-up test. Objective accommodation was measured with the Grand Seiko auto-refractor and a Badal lens system. Lens thickness was measured with the Zeiss Visante OCT and an internal optometer. The data were analysed using correlation coefficients, linear regression, and by calculating the average change in lens thickness per diopter change in objective accommodation.
RESULTS
Twenty-two subjects between the ages of 36 and 50 years completed the study. Subjective amplitude of accommodation ranged from 2.17 to 6.38 D. Objective accommodation ranged from 0.22 to 4.56 D. The mean lens thickness was 4.05+/-0.20 mm. The mean change in lens thickness for up to a 5-D accommodative stimulus ranged from 0.01 to 0.26 mm. The correlation coefficients were: age and subjective accommodation, r= -0.74; age and objective accommodation, r= -0.84; change in lens thickness and age, r= -0.65; change in lens thickness and subjective accommodation, r=0.74; change in lens thickness and objective accommodation, r=0.64; objective and subjective accommodation, r=0.82 (all p<0.01). An increase in lens thickness of 21 microm per year of age was determined by linear regression. For the subjects who showed at least 1 D of accommodative response on the Grand Seiko auto-refractor, there was an increase of 51+/-19 microm per dioptre of accommodation.
CONCLUSIONS
Optical coherence tomography is a non-invasive technique that can be used to quantify changes in the thickness of the crystalline lens. Subjective and objective measurements of accommodation, as well as age, were robustly correlated with the measured changes in lens thickness. Lens thickness changes with age and accommodation as measured with the Visante OCT compare well with previous findings using Scheimpflug photography and ultrasound.
目的
利用时域光学相干断层扫描（OCT）测量晶状体随年龄和调节的变化。
方法
对未老花和老花的受试者进行横断面研究。通过上推试验测量调节幅度。使用精工自动验光仪和巴达尔透镜系统测量客观调节。使用蔡司Visante OCT和内部验光仪测量晶状体厚度。使用相关系数、线性回归以及通过计算客观调节每屈光度变化时晶状体厚度的平均变化来分析数据。
结果
22名年龄在36至50岁之间的受试者完成了研究。主观调节幅度范围为2.17至6.38 D。客观调节范围为0.22至4.56 D。晶状体平均厚度为4.05±0.20 mm。高达5 D调节刺激下晶状体厚度的平均变化范围为0.01至0.26 mm。相关系数分别为：年龄与主观调节，r = -0.74；年龄与客观调节，r = -0.84；晶状体厚度变化与年龄，r = -0.65；晶状体厚度变化与主观调节，r = 0.74；晶状体厚度变化与客观调节，r = 0.64；客观与主观调节，r = 0.82（均p<0.01）。通过线性回归确定，年龄每增加一岁，晶状体厚度增加21微米。对于在精工自动验光仪上显示至少1 D调节反应的受试者，每屈光度调节晶状体厚度增加51±19微米。
结论
光学相干断层扫描是一种可用于量化晶状体厚度变化的非侵入性技术。调节的主观和客观测量以及年龄与所测量的晶状体厚度变化密切相关。使用Visante OCT测量的晶状体厚度随年龄和调节的变化与先前使用Scheimpflug摄影和超声的研究结果相当。
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