Department of Ophthalmology, International University of Health and Welfare School of Medicine, 852 Hatakeda, Narita City, 286-0124, Chiba Prefecture, Japan.
Department of Ophthalmology and Visual Sciences, Yamagata University Faculty of Medicine, Yamagata City, Yamagata, Japan.
Jpn J Ophthalmol. 2024 Nov;68(6):751-763. doi: 10.1007/s10384-024-01126-7. Epub 2024 Oct 2.
To investigate the associations of tomographic parameters in anterior segment optical coherence tomography (AS-OCT) with sex and age in a cohort study.
A cohort design.
AS-OCT data from 391 Japanese participants aged ≥ 35 years were obtained using swept-source OCT. In the cornea, the keratometric power at the flat (Kf) and steep (Ks) meridians, maximum keratometric power (Kmax), keratometric cylinder, spherical power, regular astigmatism, asymmetry, higher-order irregularity (HOI) from the anterior and posterior surfaces, and the central and thinnest corneal thicknesses were evaluated. Also, anterior chamber depth (ACD), lens thickness, crystalline lens rise (CLR), and nasal and temporal angle opening distances at 500 μm from the scleral spur (AOD500) were assessed. Sex differences and age-related changes were analyzed.
Women exhibited higher anterior Kf, Ks, and Kmax and lower posterior Kf, Ks, and Kmax than men. The ACD and nasal/temporal AOD500 were shorter in women than in men. The CLR was higher in women, whereas the lens thickness did not differ between the sexes, indicating a more anteriorly positioned lens in women. Age-related changes included increased anterior/posterior HOI, increased lens thickness and CLR resulting in decreased ACD and AOD500.
This study reveals sex-related differences in corneal shape, anterior chamber conformation, and lens position, as well as age-related changes in tomographic parameters. ACD, CLR, nasal and temporal AOD500 showed significant sex differences in the 50-70 s, whereas lens thickness showed no difference.
通过队列研究探讨眼前节光学相干断层扫描（AS-OCT）中的断层参数与性别和年龄的相关性。
队列设计。
使用扫频源 OCT 从 391 名年龄≥35 岁的日本参与者中获取 AS-OCT 数据。在角膜中，评估了在平坦（Kf）和陡峭（Ks）子午线处的角膜曲率力、最大角膜曲率力（Kmax）、角膜曲率力、球镜力、规则散光、不对称性、前表面和后表面的高阶不规则性（HOI）以及中央和最薄角膜厚度。此外，还评估了前房深度（ACD）、晶状体厚度、晶状体上升（CLR）以及巩膜突 500μm 处的鼻侧和颞侧开口距离（AOD500）。分析了性别差异和年龄相关的变化。
女性的前 Kf、Ks 和 Kmax 较高，后 Kf、Ks 和 Kmax 较低。女性的 ACD 和鼻侧/颞侧 AOD500 较短。女性的 CLR 较高，而晶状体厚度在性别之间没有差异，这表明女性的晶状体位置更靠前。年龄相关的变化包括前/后 HOI 增加、晶状体厚度和 CLR 增加导致 ACD 和 AOD500 减少。
本研究揭示了角膜形状、前房形态和晶状体位置的性别差异，以及断层参数的年龄相关性变化。ACD、CLR、鼻侧和颞侧 AOD500 在 50-70 岁时表现出显著的性别差异，而晶状体厚度则没有差异。
