膜氧化还原状态与细胞凋亡：过氧化氢导致的死亡
Membrane redox state and apoptosis: death by peroxide.
作者信息
Loscalzo Joseph
机构信息
Department of Medicine, Brigham and Women's Hospital, 75 Francis Street, Harvard Medical School, Boston, MA 02118-2394, USA.
出版信息
Cell Metab. 2008 Sep;8(3):182-3. doi: 10.1016/j.cmet.2008.08.004.
PMID:18762018
Abstract
Membrane redox state is governed by the complex interplay between oxidation of unsaturated fatty acids and lipophilic antioxidants. In this issue of Cell Metabolism, Seiler et al. (2008) show that a lipid oxidase, 12/15-lipoxygenase, and a membrane antioxidant enzyme, glutathione peroxidase-4, interact to regulate a novel redox-dependent cell death pathway.
摘要
膜氧化还原状态由不饱和脂肪酸氧化与亲脂性抗氧化剂之间的复杂相互作用所调控。在本期《细胞代谢》中，塞勒等人（2008年）表明，一种脂质氧化酶，即12/15-脂氧合酶，与一种膜抗氧化酶，即谷胱甘肽过氧化物酶-4，相互作用以调控一条新的氧化还原依赖性细胞死亡途径。
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