在绝对不吸烟和不饮酒的舌鳞状细胞癌患者中未检测到高危型人乳头瘤病毒——7例患者的病例研究
No high-risk HPV detected in SCC of the oral tongue in the absolute absence of tobacco and alcohol--a case study of seven patients.
作者信息
Siebers T J H, Merkx M A W, Slootweg P J, Melchers W J G, van Cleef P, de Wilde P C M
机构信息
Department of Oral and Maxillofacial Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
出版信息
Oral Maxillofac Surg. 2008 Dec;12(4):185-8. doi: 10.1007/s10006-008-0131-7.
INTRODUCTION
In recent years, there has been an increase in the number of patients with squamous cell carcinoma (SCC) of the mobile tongue in the absence of tobacco and alcohol. The literature suggests that human papilloma virus (HPV) may be involved in the development of SCC of the head and neck, especially in non-smoking and non-drinking patients. In the oral cavity, however, the presence of the HPV genome has been reported with various percentages. This may be due to misclassification of the oropharyngeal tongue as oral cavity subsite and the use of various detection methods.
MATERIALS AND METHODS
Therefore, we evaluated the role of HPV in seven consecutive non-smoking and non-drinking patients (2003-2006) with a SCC located at the oral, mobile tongue using in situ hybridization and SPF(10)Line Blot 25 polymerase chain reaction assays.
RESULTS
No HPV was detected in these specimens. To further determine whether a relationship exists between HPV and SCC in the absence of tobacco and alcohol, subsequent studies at specific locations are necessary.
引言
近年来，在无烟草和酒精接触史的情况下，舌活动部鳞状细胞癌（SCC）患者数量有所增加。文献表明，人乳头瘤病毒（HPV）可能参与头颈部SCC的发生发展，尤其是在不吸烟和不饮酒的患者中。然而，在口腔中，HPV基因组的存在报告比例各异。这可能是由于口咽舌被误分类为口腔亚部位以及使用了各种检测方法所致。
材料与方法
因此，我们使用原位杂交和SPF(10)线性印迹25聚合酶链反应检测法，评估了7例连续的无烟草和酒精接触史（2003 - 2006年）、SCC位于口腔舌活动部的患者中HPV的作用。
结果
在这些标本中未检测到HPV。为进一步确定在无烟草和酒精接触史的情况下HPV与SCC之间是否存在关联，有必要在特定部位进行后续研究。
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