无吸烟、饮酒史的头颈部鳞癌患者存在不同分子参数的证据：HPV、p16、TP53 的系统评价和荟萃分析。
Evidence for different molecular parameters in head and neck squamous cell carcinoma of nonsmokers and nondrinkers: Systematic review and meta-analysis on HPV, p16, and TP53.
机构信息
Department of Otorhinolaryngology and Head & Neck Surgery, GROW-school for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands.
Department of Oral and Cranio-Maxillofacial Surgery, GROW-school for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, Netherlands.
出版信息
Head Neck. 2021 Jan;43(1):303-322. doi: 10.1002/hed.26513. Epub 2020 Oct 23.
BACKGROUND
The goal of this review was to present an overview of the currently identified molecular parameters in head and neck squamous cell carcinoma (HNSCC) of nonsmokers and nondrinkers (NSND).
METHODS
Following the PRISMA guidelines, a systematic search was performed using the electronic databases PubMed, Embase, and Google Scholar.
RESULTS
Of the 902 analyzed unique studies, 74 were included in a quantitative synthesis and 24 in a meta-analysis. Human papillomavirus (HPV) was reported as a molecular parameter in 38 studies, followed by p16 and TP53 (23 and 14 studies, respectively). The variety of other molecular parameters concerned sporadic findings in small numbers of NSND.
CONCLUSIONS
HNSCC in NSND is more often related to HPV and p16 overexpression compared to tumors of smokers-drinkers. In a third of virus-negative tumors, TP53 mutations were detected with a mutational profile associated with aging and ultraviolet light exposure rather than to tobacco consumption.
背景
本综述旨在介绍非吸烟、非饮酒的头颈部鳞状细胞癌（NSND）患者目前已确定的分子参数概述。
方法
根据 PRISMA 指南，使用电子数据库 PubMed、Embase 和 Google Scholar 进行了系统搜索。
结果
在分析的 902 项独特研究中，有 74 项被纳入定量综合分析，24 项被纳入荟萃分析。有 38 项研究报道了人乳头瘤病毒（HPV）是一个分子参数，其次是 p16 和 TP53（分别有 23 项和 14 项研究）。其他分子参数的多样性涉及到 HPV 阴性的少量 NSND 肿瘤中的偶发发现。
结论
与吸烟者-饮酒者的肿瘤相比，NSND 的 HNSCC 更常与 HPV 和 p16 过表达相关。在三分之一的病毒阴性肿瘤中，检测到 TP53 突变，其突变谱与衰老和紫外线暴露有关，而与烟草消费无关。
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