Császár Albert
Allami Egészségügyi Központ, II. Belgyógyászati Osztály, Budapest.
Ideggyogy Sz. 2008 Jul 30;61(7-8):239-43.
Statin's treatment clearly is authorized in prevention of coronary heart disease (CHD). According to the results of many studies and meta-analyses statins can inhibit the first cerebrovascular infarct (stroke). The greater the decrease of LDL-cholesterol level the more prominent the efficacy. The effect is not so robust compared to coronary vessels moreover clear pleiotropic (cholesterol independent) action takes also part. It has been nowadays revealed that high dose (80 mg) atorvastatin can confine first time the development of recurrence stroke (SPARCL study), which is an important fact in the field of secondary prevention.
他汀类药物治疗在预防冠心病（CHD）方面显然是被认可的。根据许多研究和荟萃分析的结果，他汀类药物可抑制首次脑血管梗死（中风）。低密度脂蛋白胆固醇水平下降幅度越大，疗效越显著。与冠状动脉相比，其作用没那么强劲，而且还存在明显的多效性（不依赖胆固醇）作用。如今已发现，高剂量（80毫克）阿托伐他汀可首次限制复发性中风的发生（SPARCL研究），这在二级预防领域是一个重要事实。
