Spivak N Ia, Sukhikh G T, Bogdanova I M, Malaĭtsev V V, Shevchuk V A
Fiziol Zh (1994). 2008;54(3):92-104.
In the review it has been presented the conceptional analysis of modern state of stem cells use problem (SC) in gene therapy ex vivo. Principles of vectorial systems construction have been expounded, designed for SC transfection. It has been displayed results of experimental investigations and clinical data on transplantation of genetically modifiable SC at different monogenous and multifactorial diseases. Special attention is focused on the problem of biosecurity ensuring.
在这篇综述中，介绍了体外基因治疗中干细胞应用问题（SC）的现代状况的概念分析。阐述了为干细胞转染设计的载体系统构建原则。展示了针对不同单基因和多因素疾病进行基因修饰干细胞移植的实验研究结果和临床数据。特别关注生物安全保障问题。
