α-连接的2-脱氧糖苷的直接和立体选择性合成。
Direct and stereoselective synthesis of alpha-linked 2-deoxyglycosides.
作者信息
Park Jin, Boltje Thomas J, Boons Geert-Jan
机构信息
Complex Carbohydrate Research Center, The University of Georgia, 315 Riverbend Road, Athens, Georgia 30602, USA.
出版信息
Org Lett. 2008 Oct 2;10(19):4367-70. doi: 10.1021/ol801833n. Epub 2008 Sep 3.
Abstract
alpha-Linked 2-deoxyglycosides were conveniently obtained by employing a glycosyl donor having a participating ( S)-(phenylthiomethyl)benzyl moiety at C-6, whereas 2,6-dideoxy-alpha-glycosides could be prepared by BF 3.Et 2O-promoted activation of allyl glycosyl donors.
摘要
通过使用在C-6位具有参与性（S）-（苯硫基甲基）苄基部分的糖基供体，可以方便地获得α-连接的2-脱氧糖苷，而2,6-二脱氧-α-糖苷可以通过BF₃·Et₂O促进的烯丙基糖基供体的活化来制备。
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