School of Chemistry, University of Bristol , Cantock's Close, Bristol BS8 1TS, United Kingdom.
J Am Chem Soc. 2017 Oct 11;139(40):14041-14044. doi: 10.1021/jacs.7b08898. Epub 2017 Sep 28.
Au(I) in combination with AgOTf enables the unprecedented direct and α-stereoselective catalytic synthesis of deoxyglycosides from glycals. Mechanistic investigations suggest that the reaction proceeds via Au(I)-catalyzed hydrofunctionalization of the enol ether glycoside. The room temperature reaction is high yielding and amenable to a wide range of glycal donors and OH nucleophiles.
金（I）与三氟甲磺酸银的结合使去氧糖苷能够以前所未有的直接和 α-立体选择性方式从糖醛得到催化合成。机理研究表明，反应通过烯醇醚糖苷的金（I）催化氢官能化进行。该室温反应具有高产率，并且适用于广泛的糖醛供体和 OH 亲核试剂。
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