螺旋星孢菌素B：南部（C9 - C25）区域的合成

Spirastrellolide B: the synthesis of southern (C9-C25) region.

作者信息

Chandrasekhar Srivari, Rambabu Chegondi, Reddy Annareddy Syamprasad

机构信息

Organic Division-I, Indian Institute of Chemical Technology, Hyderabad, India.

出版信息

Org Lett. 2008 Oct 2;10(19):4355-7. doi: 10.1021/ol801771s. Epub 2008 Sep 3.

DOI:10.1021/ol801771s

PMID:18763800

Abstract

A combination of "chiron" and "asymmetric" approaches is utilized to construct the southern (C 9-C 25) region of marine natural product spirastrellolide B. The key functionalities are derived from d-glucose and Sharpless asymmetric epoxidation and dihydroxylation.

摘要

采用“手性合成子”和“不对称”方法相结合的方式构建海洋天然产物螺旋星孢菌素B的南部（C9 - C25）区域。关键官能团来源于d - 葡萄糖以及夏普莱斯不对称环氧化和二羟基化反应。