Zhang Dongxian, Owens Cabe M, Willis William D
Department of Anatomy and Neurosciences, and Marine Biomedical Institute, University of Texas Medical Branch, Galveston, TX 77550 U.S.A.
Pain. 1991 May;45(2):197-201. doi: 10.1016/0304-3959(91)90188-4.
The responses of 8 wide-dynamic-range (WDR) STT neurons to electrical stimulation of the sensorimotor cortex or the cerebral peduncle were recorded intracellularly in anesthetized monkeys. EPSPs and spikes were evoked in STT neurons with short latencies ranging from 0.4 to 5.3 msec after the corticospinal volley, indicating a monosynaptic connection in at least some STT neurons. Spatial and temporal summation seem necessary for the cortex to maintain an effective excitatory influence on STT neurons. It is postulated that the cortical facilitation of STT neurons helps them to acquire more nociceptive signals during behavioral tasks such as exploring a new object so that the brain can make decisions about whether to continue or to abandon a certain task. Possible implications for central pain states are discussed.
在麻醉的猴子中，细胞内记录了8个宽动态范围（WDR）脊髓丘脑束（STT）神经元对感觉运动皮层或脑桥的电刺激的反应。在皮质脊髓冲动后0.4至5.3毫秒的短潜伏期内，STT神经元诱发了兴奋性突触后电位（EPSP）和动作电位，表明至少在一些STT神经元中存在单突触连接。空间和时间总和似乎是皮层对STT神经元维持有效兴奋性影响所必需的。据推测，皮层对STT神经元的易化作用有助于它们在诸如探索新物体等行为任务中获取更多伤害性信号，以便大脑能够决定是否继续或放弃某项任务。文中讨论了对中枢性疼痛状态的可能影响。
