Aydin Hakan, Zhou Ming
Department of Pathology, Cleveland Clinic Taussig Cancer Center, 9500 Euclid Avenue L25, Cleveland, OH, USA.
Curr Oncol Rep. 2008 May;10(3):235-44. doi: 10.1007/s11912-008-0036-5.
Renal cell carcinoma (RCC), which arises from the renal tubular epithelial cells, accounts for more than 90% of primary renal tumors in adults. This article reviews the current literature on RCC, including the new histologic subtypes that were included in the latest World Health Organization classification. It also reviews the conventional histopathologic prognostic parameters, potential prognostic biomarkers, and molecular profiling of RCC. Evolving understanding of genetics, coupled with morphologic and immunophenotypic characteristics, should enable more precise categorization of RCCs for diagnosis and clinical behavior and, hence, better stratification of patients for the most beneficial treatment.
肾细胞癌（RCC）起源于肾小管上皮细胞，占成人原发性肾肿瘤的90%以上。本文综述了有关肾细胞癌的当前文献，包括最新世界卫生组织分类中纳入的新组织学亚型。它还综述了肾细胞癌的传统组织病理学预后参数、潜在预后生物标志物和分子谱。对遗传学的不断深入理解，结合形态学和免疫表型特征，应能更精确地对肾细胞癌进行分类以用于诊断和临床行为分析，从而更好地对患者进行分层以实施最有益的治疗。
