Kalyanaraman Balaji, Gaitonde Krishnanath, Donovan James F
Division of Urology, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.
Indian J Urol. 2009 Oct-Dec;25(4):485-8. doi: 10.4103/0970-1591.57922.
Small renal masses (SRMs) are renal tumors less than 4 cm in diameter. These account for the largest proportion of newly diagnosed renal cell cancers (RCC). Management of SRMs can be a dilemma if the patient is unfit to undergo partial nephrectomy. Molecular profiling enables better characterization of RCC and prediction of outcomes in terms of recurrence and progression. This article reviews the existing literature on molecular profiling of localized RCC, discusses limitations of molecular profiling, and presents the likely role that molecular profiling will play in guiding the treatment of SRMs.
小肾肿块（SRMs）是直径小于4厘米的肾肿瘤。这些肿瘤在新诊断的肾细胞癌（RCC）中占比最大。如果患者不适合接受部分肾切除术，那么小肾肿块的管理可能会成为一个难题。分子谱分析能够更好地对肾细胞癌进行特征描述，并预测复发和进展方面的预后。本文回顾了关于局限性肾细胞癌分子谱分析的现有文献，讨论了分子谱分析的局限性，并阐述了分子谱分析在指导小肾肿块治疗中可能发挥的作用。
