Lehmacher W
Gesellschaft für Strahlen- und Umweltforschung (GSF), Institut für Medizinische Informatik und Systemforschung, Neuherberg, West Germany.
Stat Med. 1991 Jun;10(6):891-9. doi: 10.1002/sim.4780100610.
When a residual effect is suspected in a two-period crossover trial, an analysis of the first-period data is often chosen instead of the potentially biased crossover analysis. This paper indicates how the usual crossover test has to be interpreted correctly and that its bias has two different consequences, namely a conservative or a liberal test decision if a positive (carryover) or a negative (withdrawal) residual effect exists. A multiple testing procedure is presented allowing for simultaneous crossover and first-period analysis controlling the experimental error rate. This procedure together with the correct interpretation of the crossover test enables many useful applications of crossover designs.
在两阶段交叉试验中，当怀疑存在残留效应时，通常会选择对第一阶段的数据进行分析，而不是采用可能存在偏差的交叉分析。本文指出了如何正确解读常规交叉检验，并且其偏差有两种不同的结果，即如果存在正向（延滞）或负向（撤药）残留效应，检验决策会偏保守或偏宽松。本文提出了一种多重检验程序，可同时进行交叉分析和第一阶段分析，控制实验错误率。该程序与交叉检验的正确解读相结合，使得交叉设计有许多有用的应用。
