来自雪白盘菌的四环萜类化合物，达西环菌素D和E。

Tetracyclic terpenoids from Dasyscyphus niveus, dasyscyphins D and E.

作者信息

Liermann Johannes C, Kolshorn Heinz, Anke Heidrun, Thines Eckhard, Opatz Till

机构信息

Institut für Organische Chemie, Universität Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany.

出版信息

J Nat Prod. 2008 Sep;71(9):1654-6. doi: 10.1021/np800355a. Epub 2008 Sep 5.

DOI:10.1021/np800355a

PMID:18771321

Abstract

Cultures of the ascomycete Dasyscyphus niveus have yielded two new tetracyclic dasyscyphin-type terpenoids (1 and 2), and their structures were elucidated by NMR spectroscopy and X-ray crystallography. The absolute configuration of dasyscyphin D (1) was determined by synthesis and NMR spectroscopy of diastereomeric MTPA esters. Both compounds inhibited the germination of conidia of Magnaporthe grisea at 25 microg/mL.

摘要

子囊菌白雪盘菌（Dasyscyphus niveus）的培养物产生了两种新的四环盘菌素型萜类化合物（1和2），其结构通过核磁共振光谱和X射线晶体学得以阐明。盘菌素D（1）的绝对构型通过非对映体MTPA酯的合成和核磁共振光谱确定。两种化合物在25微克/毫升时均能抑制稻瘟病菌分生孢子的萌发。