来自一种（柔膜菌目，子囊菌门）真菌的具有细胞毒性和抗菌活性的菖蒲烷半萜类化合物。
Cytotoxic and antimicrobial drimane meroterpenoids from a fungus of the (Ostropales, Ascomycota).
作者信息
Flores-Bocanegra Laura, Augustinović Mario, Raja Huzefa A, Kurina Steven J, Maldonado Amanda C, Burdette Joanna E, Falkinham Joseph O, Pearce Cedric J, Oberlies Nicholas H
机构信息
Department of Chemistry and Biochemistry, University of North Carolina at Greensboro, Greensboro, North Carolina 27402, United States.
Department of Pharmaceutical Sciences, University of Illinois at Chicago, Chicago, Illinois 60612, United States.
出版信息
Tetrahedron Lett. 2021 Mar 30;68. doi: 10.1016/j.tetlet.2021.152896. Epub 2021 Feb 5.
As part of our ongoing research on bioactive fungal metabolites, two new metabolites were isolated from a fungus of the (strain MSX62440), dasyscyphins F and G ( and ), and the known dasyscyphin C (). Compound was characterized by HRMS and 1D and 2D NMR data, and its absolute configuration established by ECD spectroscopy. A structural revision of dasyscyphin C () was based on NMR data and verified by ECD calculations. Compound was reported previously as a synthetic product, and its identity confirmed by comparison with NMR data in the literature, and its absolute configuration was established by ECD spectroscopy. Compounds and showed moderate cytotoxicity and antimicrobial activity.
作为我们正在进行的生物活性真菌代谢产物研究的一部分，从一种真菌（菌株MSX62440）中分离出两种新的代谢产物，达西菌素F和G（结构简式分别为[具体结构简式1]和[具体结构简式2]），以及已知的达西菌素C（结构简式为[具体结构简式3]）。化合物[具体化合物编号]通过高分辨质谱（HRMS）以及一维和二维核磁共振（NMR）数据进行表征，并通过电子圆二色光谱（ECD）确定其绝对构型。基于核磁共振数据对达西菌素C（[具体结构简式3]）进行了结构修正，并通过ECD计算进行了验证。化合物[具体化合物编号]之前被报道为合成产物，通过与文献中的核磁共振数据比较确认了其结构，并通过ECD光谱确定了其绝对构型。化合物[具体化合物编号]和[具体化合物编号]表现出中等程度的细胞毒性和抗菌活性。
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