Alanis Mark C, Robinson Christopher J, Hulsey Thomas C, Ebeling Myla, Johnson Donna D
Department of Obstetrics and Gynecology, Medical University of South Carolina, Charleston, SC, USA.
Am J Obstet Gynecol. 2008 Sep;199(3):262.e1-6. doi: 10.1016/j.ajog.2008.06.076.
The purpose of this study was to describe the success rate of and analyze differences in neonatal outcomes with labor induction, compared with elective cesarean delivery in women with early-onset severe preeclampsia.
We conducted a cross-sectional study of women with severe preeclampsia who required delivery between 24 and 34 weeks of gestation. Bivariate and multivariable regression analyses were used to determine factors that were associated with assignment to, success of, and odds of neonatal outcomes after induction of labor.
Fifty-seven and four-tenths percent of 491 women underwent induction of labor. Vaginal delivery occurred in 6.7%, 47.5%, and 68.8% of women who underwent labor induction between 24 and 28, 28 and 32, and 32 and 34 weeks of gestation, respectively. Induction of labor was not associated with an increase in neonatal morbidity or mortality rate after we controlled for gestational age and other confounders.
Neonatal outcomes are not worsened by induction of labor in women with early-onset severe preeclampsia, although it is rarely successful at <28 weeks of gestation.
本研究旨在描述早发型重度子痫前期孕妇引产的成功率，并分析与择期剖宫产相比，引产的新生儿结局差异。
我们对妊娠24至34周需要分娩的重度子痫前期孕妇进行了一项横断面研究。采用双变量和多变量回归分析来确定与引产分配、引产成功以及引产后新生儿结局几率相关的因素。
491名女性中有57.4%接受了引产。在妊娠24至28周、28至32周以及32至34周接受引产的女性中，阴道分娩率分别为6.7%、47.5%和68.8%。在我们控制了胎龄和其他混杂因素后，引产与新生儿发病率或死亡率的增加无关。
早发型重度子痫前期孕妇引产不会使新生儿结局恶化，尽管在妊娠<28周时引产很少成功。
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