Orvedahl A, Levine B
Howard Hughes Medical Institute and Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75390, USA.
Cell Death Differ. 2009 Jan;16(1):57-69. doi: 10.1038/cdd.2008.130. Epub 2008 Sep 5.
Autophagy is emerging as a central component of antimicrobial host defense against diverse viral, bacterial, and parasitic infections. In addition to pathogen degradation, autophagy has other functions during infection such as innate and adaptive immune activation. As an important host defense pathway, microbes have also evolved mechanisms to evade, subvert, or exploit autophagy. Additionally, some fungal pathogens harness autophagy within their own cells to promote pathogenesis. This review will highlight our current understanding of autophagy in infection, focusing on the most recent advances in the field, and will discuss the potential implications of these studies in the design of anti-infective therapeutics.
自噬正逐渐成为宿主抵御各种病毒、细菌和寄生虫感染的抗菌防御的核心组成部分。除了病原体降解外，自噬在感染过程中还具有其他功能，如天然免疫和适应性免疫激活。作为一种重要的宿主防御途径，微生物也进化出了逃避、破坏或利用自噬的机制。此外，一些真菌病原体利用自身细胞内的自噬来促进致病作用。本综述将重点介绍我们目前对感染中自噬的理解，聚焦于该领域的最新进展，并讨论这些研究在抗感染治疗设计中的潜在意义。
