在长期使用氨磺必利治疗的基础上加用奥卡西平后出现无发热的抗精神病药恶性综合征。
Neuroleptic malignant syndrome without fever after addition of oxcarbazepine to long-term treatment with amisulpride.
作者信息
Angelopoulos Petros, Markopoulou Maria, Kyamidis Kyriakos, Bobotas Konstantinos
机构信息
General Hospital of Thessaloniki, Greece.
出版信息
Gen Hosp Psychiatry. 2008 Sep-Oct;30(5):482-4. doi: 10.1016/j.genhosppsych.2008.03.007. Epub 2008 Jul 23.
OBJECTIVE
Our goal was to report a case of malignant neuroleptic syndrome in a patient administered with both oxcarbazepine (OXCBZ) and amisulpride (AM).
METHOD
We present a case of a young man who presented with symptoms of malignant neuroleptic syndrome after progressive titration of OXCBZ (1,200 mg) added to the long-term treatment with AM (800 mg).
RESULTS
After discontinuation of AM and administration of dopaminergic drugs, his clinical symptoms improved gradually.
CONCLUSION
This case suggests that clinicians should consider the risk of neuroleptic malignant syndrome when OXCBZ is coadministered to patients undergoing long-term treatment with neuroleptics.
目的
我们的目标是报告一例同时服用奥卡西平（OXCBZ）和氨磺必利（AM）的患者发生恶性抗精神病药物综合征的病例。
方法
我们报告一例年轻男性病例，该患者在长期服用AM（800毫克）的基础上逐渐滴定增加OXCBZ（1200毫克）后出现恶性抗精神病药物综合征症状。
结果
停用AM并给予多巴胺能药物后，他的临床症状逐渐改善。
结论
该病例提示，临床医生在给长期服用抗精神病药物的患者联合使用OXCBZ时应考虑抗精神病药物恶性综合征的风险。
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