Sánchez Francesca, Gimeno-Bayón Juan Luis, Esgueva Raquel, Alvarez Francisco, Munné Ma Assumpta, Serrano Sergi
Services of Internal Medicine and Infectious Diseases, Hospital del Mar. Barcelona, 08003 Barcelona, Spain.
Ann Diagn Pathol. 2008 Oct;12(5):368-71. doi: 10.1016/j.anndiagpath.2007.01.008. Epub 2007 Oct 18.
Epstein-Barr virus (EBV) infection is a benign disease, which may occasionally be fatal, particularly in children and immunocompromised patients. Epstein-Barr virus infection is rare in elderly subjects and seems to have a self-limited course. A case of fatal liver failure due to chronic active EBV infection in a 75-year-old man is described. The etiology was established postmortem by cellular expression of EBV-DNA in liver and lymphatic tissue. This patient meets the diagnostic criteria of a case definition for a highly probable "severe chronic active EBV syndrome." Either suspected or unsuspected, the long-term prognosis of this syndrome is poor and its mortality high.
爱泼斯坦-巴尔病毒（EBV）感染是一种良性疾病，但偶尔可能致命，尤其是在儿童和免疫功能低下的患者中。爱泼斯坦-巴尔病毒感染在老年患者中较为罕见，且似乎具有自限性病程。本文描述了一例75岁男性因慢性活动性EBV感染导致致命性肝衰竭的病例。病因在尸检时通过肝脏和淋巴组织中EBV-DNA的细胞表达得以确定。该患者符合高度可能的“严重慢性活动性EBV综合征”病例定义的诊断标准。无论是否被怀疑，该综合征的长期预后都很差，死亡率很高。
