由爱泼斯坦-巴尔病毒感染引起的暴发性肝炎。

Fulminant hepatitis due to Epstein-Barr virus infection.

作者信息

Papatheodoridis G V, Delladetsima J K, Kavallierou L, Kapranos N, Tassopoulos N C

机构信息

First Department of Medicine, Western Attica General Hospital, Athens, Greece.

出版信息

J Hepatol. 1995 Sep;23(3):348-50.

PMID:8551000

Abstract

Epstein-Barr virus infection is a benign disease, which may occasionally be fatal, particularly in children. Epstein-Barr virus infection is rare in elderly subjects and appears to have a self-limited course. An unusual case of fulminant hepatitis due to primary Epstein-Barr virus infection in a 62-year-old male 18 days after a cardiosurgical operation and blood transfusions is described in the present paper. Post-mortem examination of the liver showed massive hepatic necrosis. The etiology was established by increase in IgM antibodies to Epstein-Barr virus (titer 1:3.120) in serum and by cellular expression of Epstein-Barr virus DNA in liver tissue.

摘要

爱泼斯坦-巴尔病毒感染是一种良性疾病，但偶尔可能致命，尤其是在儿童中。爱泼斯坦-巴尔病毒感染在老年患者中罕见，且似乎病程自限。本文描述了一例62岁男性在心脏外科手术和输血18天后因原发性爱泼斯坦-巴尔病毒感染导致暴发性肝炎的不寻常病例。肝脏尸检显示大量肝坏死。病因通过血清中抗爱泼斯坦-巴尔病毒IgM抗体升高（滴度1:3120）以及肝组织中爱泼斯坦-巴尔病毒DNA的细胞表达得以确定。