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卵裂球活检对植入前小鼠胚胎发育及整体基因表达的影响。

The effect of blastomere biopsy on preimplantation mouse embryo development and global gene expression.

作者信息

Duncan Francesca E, Stein Paula, Williams Carmen J, Schultz Richard M

机构信息

Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

出版信息

Fertil Steril. 2009 Apr;91(4 Suppl):1462-5. doi: 10.1016/j.fertnstert.2008.07.1710. Epub 2008 Sep 6.

DOI:10.1016/j.fertnstert.2008.07.1710
PMID:18774571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2683241/
Abstract

The blastomere biopsy procedure does not affect preimplantation embryo development or global patterns of gene expression in a mouse model of Preimplantation Genetic Testing (PGT). However, zona breaching, which is inherent to the blastomere biopsy procedure, causes significant premature and sometimes abnormal hatching.

摘要

在胚胎植入前遗传学检测（PGT）小鼠模型中，卵裂球活检程序不会影响植入前胚胎发育或基因表达的整体模式。然而，卵裂球活检程序所固有的透明带破裂会导致显著的过早孵化，有时还会出现异常孵化。

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本文引用的文献

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Dichorionic triamniotic triplet pregnancy with monozygotic twins discordant for trisomy 13 after preimplantation genetic screening: case report.植入前基因筛查后出现的双绒毛膜三羊膜囊三胎妊娠，其中单卵双胎之一为13三体，另一个正常：病例报告
Fertil Steril. 2008 Nov;90(5):2017.e5-9. doi: 10.1016/j.fertnstert.2008.01.095. Epub 2008 Apr 9.
2
Preimplantation genetic testing: a Practice Committee opinion.植入前基因检测：实践委员会意见
Fertil Steril. 2007 Dec;88(6):1497-504. doi: 10.1016/j.fertnstert.2007.10.010. Epub 2007 Oct 17.
3
Effect of in vitro fertilization on gene expression and development of mouse preimplantation embryos.体外受精对小鼠植入前胚胎基因表达和发育的影响。
Reproduction. 2007 Jul;134(1):63-72. doi: 10.1530/REP-06-0247.
4
Removal of 2 cells from cleavage stage embryos is likely to reduce the efficacy of chromosomal tests that are used to enhance implantation rates.从卵裂期胚胎中移除2个细胞可能会降低用于提高着床率的染色体检测的效能。
Fertil Steril. 2007 Mar;87(3):496-503. doi: 10.1016/j.fertnstert.2006.07.1516. Epub 2006 Dec 4.
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Is there increased monozygotic twinning after assisted reproductive technology?辅助生殖技术后单卵双胎发生率会增加吗？
Aust N Z J Obstet Gynaecol. 2005 Oct;45(5):360-4. doi: 10.1111/j.1479-828X.2005.00451.x.
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