Duncan Francesca E, Stein Paula, Williams Carmen J, Schultz Richard M
Center for Research on Reproduction and Women's Health, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Fertil Steril. 2009 Apr;91(4 Suppl):1462-5. doi: 10.1016/j.fertnstert.2008.07.1710. Epub 2008 Sep 6.
The blastomere biopsy procedure does not affect preimplantation embryo development or global patterns of gene expression in a mouse model of Preimplantation Genetic Testing (PGT). However, zona breaching, which is inherent to the blastomere biopsy procedure, causes significant premature and sometimes abnormal hatching.
在胚胎植入前遗传学检测(PGT)小鼠模型中,卵裂球活检程序不会影响植入前胚胎发育或基因表达的整体模式。然而,卵裂球活检程序所固有的透明带破裂会导致显著的过早孵化,有时还会出现异常孵化。