Nair Girish M, Nery Pablo B, Diwakaramenon Syamkumar, Healey Jeffrey S, Connolly Stuart J, Morillo Carlos A
Division of Cardiology, Arrhythmia Service, McMaster University and Hamilton Health Sciences, Ontario, Canada.
J Cardiovasc Electrophysiol. 2009 Feb;20(2):138-44. doi: 10.1111/j.1540-8167.2008.01285.x. Epub 2008 Sep 3.
Atrial fibrillation (AF) is the most frequent arrhythmia seen in clinical practice. Until recently, antiarrhythmic medications have been the only commonly employed treatment for maintaining sinus rhythm. However, antiarrhythmic medications have a modest long-term efficacy and the potential for serious side effects. Radiofrequency (RF) ablation is now emerging as a viable alternative to antiarrhythmic medications in maintaining sinus rhythm in patients with AF. Several randomized trials comparing RF ablation with antiarrhythmic medications have now been published.
To perform a systematic review of published randomized trials comparing RF ablation with antiarrhythmic medications in the treatment of AF.
A systematic review of the literature was performed and two authors independently abstracted the data from trials. A statistical analysis was performed using Comprehensive Meta-Analysis Software (BIOSTAT, Englewood, NJ, USA).
A total of six trials were identified. Overall, RF ablation reduced the risk of AF recurrence by 65% at 1 year compared with antiarrhythmic medications.
In selected patients with AF, RF ablation reduced the risk of AF recurrence at 1 year by 65% compared with antiarrhythmic medications.
心房颤动（AF）是临床实践中最常见的心律失常。直到最近，抗心律失常药物一直是维持窦性心律的唯一常用治疗方法。然而，抗心律失常药物的长期疗效一般，且有产生严重副作用的风险。射频（RF）消融目前正在成为房颤患者维持窦性心律时抗心律失常药物的一种可行替代方法。目前已经发表了几项比较射频消融与抗心律失常药物的随机试验。
对已发表的比较射频消融与抗心律失常药物治疗房颤的随机试验进行系统评价。
对文献进行系统评价，两位作者独立从试验中提取数据。使用综合荟萃分析软件（BIOSTAT，美国新泽西州恩格尔伍德）进行统计分析。
共确定了六项试验。总体而言，与抗心律失常药物相比，射频消融在1年时将房颤复发风险降低了65%。
在选定的房颤患者中，与抗心律失常药物相比，射频消融在1年时将房颤复发风险降低了65%。
