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Is an elevated burden of antiarrhythmic drug (AAD) side-effects the unavoidable price to be traded for a durable suppression of AF relapses in ablated patients? The weaknesses and risks of the AAD suppression algorithm used by current models of AF secondary prevention after catheter ablation.

作者信息

De Vecchis Renato

机构信息

Preventive Cardiology and Rehabilitation Unit, DSB 29 "S. Gennaro dei Poveri Hospital", Via S. Gennaro dei Poveri 25, 80136, Naples, Italy.

出版信息

Eur J Clin Pharmacol. 2019 Jun;75(6):873-874. doi: 10.1007/s00228-019-02638-9. Epub 2019 Jan 29.

DOI:10.1007/s00228-019-02638-9
PMID:30694340
Abstract
摘要

相似文献

1
Is an elevated burden of antiarrhythmic drug (AAD) side-effects the unavoidable price to be traded for a durable suppression of AF relapses in ablated patients? The weaknesses and risks of the AAD suppression algorithm used by current models of AF secondary prevention after catheter ablation.
Eur J Clin Pharmacol. 2019 Jun;75(6):873-874. doi: 10.1007/s00228-019-02638-9. Epub 2019 Jan 29.
2
Optimal rhythm-control strategy for recurrent atrial tachycardia after catheter ablation of persistent atrial fibrillation: a randomized clinical trial.持续性心房颤动导管消融后复发性房性心动过速的最佳节律控制策略：一项随机临床试验。
Eur Heart J. 2014 May 21;35(20):1327-34. doi: 10.1093/eurheartj/ehu017. Epub 2014 Feb 3.
3
Amiodarone after surgical ablation for atrial fibrillation: Is it really necessary? A prospective randomized controlled trial.房颤外科消融术后应用胺碘酮：真的有必要吗？一项前瞻性随机对照试验。
J Thorac Cardiovasc Surg. 2016 Mar;151(3):798-803. doi: 10.1016/j.jtcvs.2015.07.034. Epub 2015 Jul 17.
4
Antiarrhythmic drug therapy and all-cause mortality after catheter ablation of atrial fibrillation: A propensity-matched analysis.抗心律失常药物治疗与房颤导管消融术后全因死亡率：一项倾向评分匹配分析。
Heart Rhythm. 2019 Sep;16(9):1368-1373. doi: 10.1016/j.hrthm.2019.06.007. Epub 2019 Jun 12.
5
Efficacy of Antiarrhythmic Drugs Short-Term Use After Catheter Ablation for Atrial Fibrillation (EAST-AF) trial.导管消融治疗心房颤动后短期应用抗心律失常药物的疗效（EAST-AF 试验）。
Eur Heart J. 2016 Feb 14;37(7):610-8. doi: 10.1093/eurheartj/ehv501. Epub 2015 Sep 28.
6
Radiofrequency catheter ablation maintains its efficacy better than antiarrhythmic medication in patients with paroxysmal atrial fibrillation: On-treatment analysis of the randomized controlled MANTRA-PAF trial.在阵发性心房颤动患者中，射频导管消融术比抗心律失常药物能更好地维持疗效：随机对照MANTRA-PAF试验的治疗期分析。
Int J Cardiol. 2015 Nov 1;198:108-14. doi: 10.1016/j.ijcard.2015.06.160. Epub 2015 Jul 4.
7
Twelve-year follow-up of catheter ablation for atrial fibrillation: A prospective, multicenter, randomized study.心房颤动导管消融术的12年随访：一项前瞻性、多中心、随机研究。
Heart Rhythm. 2017 Apr;14(4):486-492. doi: 10.1016/j.hrthm.2016.12.023. Epub 2016 Dec 15.
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Use of antiarrhythmic drugs during ablation of persistent atrial fibrillation: observations from a large single-centre cohort.持续性心房颤动消融术中抗心律失常药物的使用：来自大型单中心队列的观察结果
Heart Vessels. 2016 Oct;31(10):1669-75. doi: 10.1007/s00380-015-0771-0. Epub 2015 Nov 6.
9
Progression of atrial fibrillation after a failed initial ablation procedure in patients with paroxysmal atrial fibrillation: a randomized comparison of drug therapy versus reablation.阵发性心房颤动患者初始消融失败后心房颤动的进展：药物治疗与再消融的随机比较。
Circ Arrhythm Electrophysiol. 2013 Aug;6(4):754-60. doi: 10.1161/CIRCEP.113.000495. Epub 2013 Jun 7.
10
Antiarrhythmic medication is superior to catheter ablation in suppressing supraventricular ectopic complexes in patients with atrial fibrillation.抗心律失常药物在抑制房颤患者的室上性异位搏动方面优于导管消融。
Int J Cardiol. 2017 Oct 1;244:186-191. doi: 10.1016/j.ijcard.2017.05.028. Epub 2017 May 10.

本文引用的文献

1
Atrial fibrillation ablation alone or atrial fibrillation ablation plus an antiarrhythmic drug?单独进行房颤消融术还是房颤消融术加抗心律失常药物？
Eur Heart J. 2018 Apr 21;39(16):1438-1441. doi: 10.1093/eurheartj/ehy120.
2
PulmOnary vein isolation With vs. without continued antiarrhythmic Drug trEatment in subjects with Recurrent Atrial Fibrillation (POWDER AF): results from a multicentre randomized trial.肺静脉隔离伴或不伴抗心律失常药物治疗复发性心房颤动患者（POWDER AF）：一项多中心随机试验的结果。
Eur Heart J. 2018 Apr 21;39(16):1429-1437. doi: 10.1093/eurheartj/ehx666.
3
Contemporary management of patients undergoing atrial fibrillation ablation: in-hospital and 1-year follow-up findings from the ESC-EHRA atrial fibrillation ablation long-term registry.
当代心房颤动消融患者的管理：ESC-EHRA 心房颤动消融长期注册研究的住院期间和 1 年随访结果。
Eur Heart J. 2017 May 1;38(17):1303-1316. doi: 10.1093/eurheartj/ehw564.
4
Cryoballoon versus Radiofrequency Catheter Ablation in Atrial Fibrillation: A Meta-Analysis.冷冻球囊与射频导管消融治疗心房颤动的Meta分析
J Cardiovasc Electrophysiol. 2016 Oct;27(10):1151-1159. doi: 10.1111/jce.13047. Epub 2016 Aug 16.
5
Rate control versus rhythm control in atrial fibrillation: lessons learned from clinical trials of atrial fibrillation.心房颤动的心率控制与节律控制：从心房颤动临床试验中获得的经验教训
Prog Cardiovasc Dis. 2015 Sep-Oct;58(2):168-76. doi: 10.1016/j.pcad.2015.08.006. Epub 2015 Aug 7.
6
The atrial fibrillation ablation pilot study: a European Survey on Methodology and results of catheter ablation for atrial fibrillation conducted by the European Heart Rhythm Association.心房颤动消融先导研究：一项由欧洲心律协会开展的关于导管消融治疗心房颤动的方法学和结果的欧洲调查。
Eur Heart J. 2014 Jun 7;35(22):1466-78. doi: 10.1093/eurheartj/ehu001. Epub 2014 Jan 31.
7
Comparison of antiarrhythmic drug therapy and radiofrequency catheter ablation in patients with paroxysmal atrial fibrillation: a randomized controlled trial.比较抗心律失常药物治疗与射频导管消融治疗阵发性心房颤动的随机对照试验。
JAMA. 2010 Jan 27;303(4):333-40. doi: 10.1001/jama.2009.2029.
8
Comparison of characteristics and significance of immediate versus early versus no recurrence of atrial fibrillation after catheter ablation.导管消融术后房颤即刻复发、早期复发与无复发的特征比较及意义
Am J Cardiol. 2009 May 1;103(9):1249-54. doi: 10.1016/j.amjcard.2009.01.010. Epub 2009 Mar 9.
9
Catheter ablation versus antiarrhythmic drugs for atrial fibrillation: the A4 study.导管消融与抗心律失常药物治疗心房颤动：A4研究
Circulation. 2008 Dec 9;118(24):2498-505. doi: 10.1161/CIRCULATIONAHA.108.772582. Epub 2008 Nov 24.
10
Atrial fibrillation progression and management: a 5-year prospective follow-up study.心房颤动的进展与管理：一项为期5年的前瞻性随访研究。
Heart Rhythm. 2008 Nov;5(11):1501-7. doi: 10.1016/j.hrthm.2008.08.011. Epub 2008 Aug 17.