碱基修饰的核糖核苷作为潜在的抗丙型肝炎病毒药物。
Base-modified ribonucleosides as potential anti-hepatitis C virus agents.
作者信息
Ivanov A V, Smirnova O A, Golubeva N A, Ivanov M A, Tunitskaya V L, Shipitsyn A V, Alexandrova L A
机构信息
Engelhardt Institute of Molecular Biology RAS, 119991 Moscow, Russia.
出版信息
Nucleic Acids Symp Ser (Oxf). 2008(52):619-20. doi: 10.1093/nass/nrn313.
Four novel series of base modified ribonucleoside analogues were synthesized and evaluated as potential anti-HCV agents. For two compounds notable anti-HCV activity was observed The triphosphates of bicyclic pyrimidine ribonucleosides were studied as substrates/inhibitors of HCV RNA-dependent RNA polymerase (RdRp, NS5B protein) and RNA helicase/NTPase (NS3 protein).
合成了四个新型的碱基修饰核糖核苷类似物系列，并将其作为潜在的抗丙型肝炎病毒（HCV）药物进行评估。对于两种化合物，观察到了显著的抗HCV活性。研究了双环嘧啶核糖核苷的三磷酸酯作为HCV RNA依赖性RNA聚合酶（RdRp，NS5B蛋白）和RNA解旋酶/NTP酶（NS3蛋白）的底物/抑制剂。
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