Cianci T, Zoccoli G, Lenzi P, Franzini C
Istituto di Fisiologia Umana, Università di Bologna, Italy.
Am J Physiol. 1991 Aug;261(2 Pt 2):R373-7. doi: 10.1152/ajpregu.1991.261.2.R373.
Regional blood flow (BF) changes during sleep were measured in rabbits at low, neutral, and high ambient temperatures (Ta) with radioactive microspheres. At both low and high Ta, peripheral vasomotor changes at the onset of desynchronized sleep (DS) were incompatible with thermoregulatory homeostasis. At low Ta, BF decreased in muscle (with the disappearance of shivering), whereas it increased in the arteriovenous anastomoses (AVA) and in the splanchnic bed. At high Ta, BF decreased in muscle (with the disappearance of panting) and in the AVA, whereas it increased in the splanchnic bed. An impaired central nervous regulation underlies the disruption of peripheral circulation patterns in this sleep stage. The lack of adaptive vasomotor adjustments in DS, which has little consequence in normal conditions, may become relevant in cardiovascular pathophysiology when BF redistribution through increased neurogenic vasomotor activity becomes a major compensating mechanism.
采用放射性微球法测量了处于低、中性和高环境温度（Ta）下的家兔睡眠期间局部血流（BF）变化。在低Ta和高Ta条件下，去同步化睡眠（DS）开始时外周血管舒缩变化均与体温调节稳态不相容。在低Ta时，肌肉血流减少（伴随寒战消失），而动静脉吻合支（AVA）和内脏床血流增加。在高Ta时，肌肉血流减少（伴随喘息消失），AVA血流也减少，而内脏床血流增加。中枢神经调节受损是该睡眠阶段外周循环模式紊乱的基础。在DS中缺乏适应性血管舒缩调节，这在正常情况下影响不大，但当通过增强神经源性血管舒缩活动进行血流重新分布成为主要代偿机制时，可能在心血管病理生理学中具有重要意义。
