前列腺外周带和移行带的表观扩散系数值：正常与恶性前列腺组织的比较及其与组织学分级的相关性

Apparent diffusion coefficient values in peripheral and transition zones of the prostate: comparison between normal and malignant prostatic tissues and correlation with histologic grade.

作者信息

Tamada Tsutomu, Sone Teruki, Jo Yoshimasa, Toshimitsu Shinya, Yamashita Takenori, Yamamoto Akira, Tanimoto Daigo, Ito Katsuyoshi

机构信息

Department of Radiology, Kawasaki Medical School, Okayama, Japan.

出版信息

J Magn Reson Imaging. 2008 Sep;28(3):720-6. doi: 10.1002/jmri.21503.

DOI:10.1002/jmri.21503

PMID:18777532

Abstract

PURPOSE

To investigate the utility of apparent diffusion coefficient (ADC) values for discriminating tumor in patients with prostate cancer from normal prostatic tissues in healthy adult men, and to identify correlations between ADC and histologic grade of prostate cancer.

MATERIALS AND METHODS

A total of 125 healthy male volunteers (mean age, 60 years; range, 50-86 years) and 90 prostate cancer patients (mean age, 71 years; range, 51-88 years) underwent diffusion-weighted imaging (DWI) of the prostate with a single-shot echo-planar imaging sequence using b-factors of 0 and 800 sec/mm2. ADC was measured from two locations in the peripheral zone (PZ) and two locations in the central gland (CG) in normal subjects, and tumor locations of PZ or transition zone (TZ) in patients with prostate cancer.

RESULTS

Mean ADC values of tumor regions in both PZ (1.02+/-0.25x10(-3) mm2/sec) and TZ (0.94+/-0.21x10(-3) mm2/sec) were significantly lower than those in the corresponding normal regions (1.80+/-0.27x10(-3) mm2/sec and 1.34+/-0.14x10(-3) mm2/sec, respectively) (P<0.0001 each). Furthermore, a significant negative correlation was identified between ADC in PZ cancer and tumor Gleason score (rho=-0.497, P<0.0001).

CONCLUSION

ADC values appear to provide acceptable diagnostic accuracy in both PZ and TZ.

摘要

目的

探讨表观扩散系数（ADC）值在鉴别健康成年男性前列腺癌患者肿瘤与正常前列腺组织中的作用，并确定ADC与前列腺癌组织学分级之间的相关性。

材料与方法

共有125名健康男性志愿者（平均年龄60岁；范围50 - 86岁）和90名前列腺癌患者（平均年龄71岁；范围51 - 88岁）接受了前列腺扩散加权成像（DWI），采用单次激发回波平面成像序列，b值分别为0和800 sec/mm²。在正常受试者的外周带（PZ）的两个位置和中央腺体（CG）的两个位置测量ADC，在前列腺癌患者的PZ或移行带（TZ）的肿瘤位置测量ADC。

结果

PZ肿瘤区域的平均ADC值（1.02±0.25×10⁻³ mm²/sec）和TZ肿瘤区域的平均ADC值（0.94±0.21×10⁻³ mm²/sec）均显著低于相应正常区域（分别为1.80±0.27×10⁻³ mm²/sec和1.34±0.14×10⁻³ mm²/sec）（P均<0.0001）。此外，PZ癌的ADC与肿瘤Gleason评分之间存在显著负相关（rho = -0.497，P<0.0001）。