Tamada Tsutomu, Sone Teruki, Toshimitsu Shinya, Imai Shigeki, Jo Yoshimasa, Yoshida Koji, Yamamoto Akira, Yamashita Takenori, Egashira Naoto, Nagai Kiyohisa, Fukunaga Masao
Department of Radiology, Kawasaki, Medical School, Okayama, Japan.
J Magn Reson Imaging. 2008 Mar;27(3):552-6. doi: 10.1002/jmri.21117.
To identify age-related changes and differences in the diffusion of water molecules within the prostate, through diffusion-weighted imaging (DWI) of the prostate gland in healthy adult Japanese men.
A total of 114 healthy male volunteers (mean age, 55 years; range, 24-81 years) underwent DWI of the prostate with a single-shot echo-planar imaging (EPI) sequence using b-factors of 0 and 1000 seconds/mm(2). Apparent diffusion coefficient (ADC) values of six locations in the peripheral zone (PZ) and two locations in the central gland (CG) were measured and correlations between region and age were examined.
ADC values measured within both PZ and CG regions of the prostate showed a uniform distribution, and no significant differences were found between evaluated regions. However, mean ADC values were 1.64 +/- 0.27 x 10(-3) mm(2)/second for PZ and 1.26 +/- 0.12 x 10(-3) mm(2)/second for CG, representing a significant difference. In addition, significant positive correlations were identified between ADC values for both PZ and CG regions and subject age (r = 0.526, P < 0.0001; r = 0.190, P = 0.0431, respectively).
ADC values within both PZ and CG regions of the prostate increase with age, and this must be taken into consideration when using DWI in the diagnosis of prostate cancer.
通过对健康成年日本男性前列腺进行扩散加权成像（DWI），确定前列腺内水分子扩散与年龄相关的变化及差异。
总共114名健康男性志愿者（平均年龄55岁；范围24 - 81岁）采用单次激发回波平面成像（EPI）序列，使用b值为0和1000秒/毫米²对前列腺进行DWI检查。测量外周区（PZ）六个位置和中央腺体（CG）两个位置的表观扩散系数（ADC）值，并检查区域与年龄之间的相关性。
前列腺PZ和CG区域内测量的ADC值显示出均匀分布，各评估区域之间未发现显著差异。然而，PZ的平均ADC值为1.64±0.27×10⁻³毫米²/秒，CG为1.26±0.12×10⁻³毫米²/秒，存在显著差异。此外，PZ和CG区域的ADC值与受试者年龄之间均存在显著正相关（分别为r = 0.526，P < 0.0001；r = 0.190，P = 0.0431）。
前列腺PZ和CG区域内的ADC值随年龄增加，在使用DWI诊断前列腺癌时必须考虑这一点。
