Wu Li, Zhang Guozhi, Luo Qingming, Liu Qian
Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, People's Republic of China.
Med Phys. 2008 Aug;35(8):3759-64. doi: 10.1118/1.2952647.
An anatomically realistic rat model was developed from color images of successive cryosections of a mature Sprague-Dawley rat. Images were obtained, by digital scanning, of 9475 slices with thickness of 0.02 mm. A total of 13 major organs and tissues were selected, and models of these organs and tissues constructed from the images were used for calculations of absorbed dose from external photon sources. A detailed set of conversion coefficients from kerma free-in-air to organ absorbed dose have been calculated for external monoenergetic photon beams with energies ranging from 10 keV to 10 MeV under five idealized irradiation conditions (left lateral, right lateral, dorsal-ventral, ventral-dorsal, and isotropic) using the Monte Carlo code MCNPX. Dose results are presented in form of tables as supplemental data for practical use and comparison. The influence of anatomical characteristics, including organ volume, shape, location, and orientation, on dose distributions were evaluated. It would also be possible to make internal dose assessments using the computational rat model.
利用一只成熟的斯普拉格-道利大鼠连续冷冻切片的彩色图像构建了一个解剖学逼真的大鼠模型。通过数字扫描获取了9475张厚度为0.02毫米的切片图像。总共选择了13个主要器官和组织，由这些图像构建的器官和组织模型用于计算外部光子源的吸收剂量。使用蒙特卡罗代码MCNPX，在五种理想化照射条件（左侧、右侧、背腹、腹背和各向同性）下，针对能量范围从10 keV到10 MeV的外部单能光子束，计算了一套详细的从空气比释动能到器官吸收剂量的转换系数。剂量结果以表格形式呈现，作为实际应用和比较的补充数据。评估了解剖学特征（包括器官体积、形状、位置和方向）对剂量分布的影响。使用该计算大鼠模型进行内部剂量评估也是可行的。
