Hall P D, Ahern M J, Jarvis L R, Stoll P, Jenner M A, Harley H
Department of Medicine, Flinders University of South Australia.
Ann Rheum Dis. 1991 Jul;50(7):471-6. doi: 10.1136/ard.50.7.471.
Serial liver biopsy specimens from 18 patients with rheumatoid arthritis receiving a weekly dose of methotrexate 7.5-20 mg for a minimum of 12 months were assessed semiquantitatively and by a microcomputer image analysis system. The semiquantitative histological method showed a significant increase in pericellular collagen and in overall disease while morphometry showed a significant increase in pericellular, perivenular, and portal tract collagen. There was a significant correlation between the two methods, but morphometry had the advantage of objectivity and efficiency. There was no correlation between the increase in collagen and the accumulated dose of methotrexate, which suggests that other factors in addition to methotrexate may contribute to liver injury.
对18例类风湿关节炎患者进行了连续肝脏活检，这些患者每周接受7.5 - 20毫克甲氨蝶呤治疗，疗程至少12个月，采用半定量法并通过微机图像分析系统进行评估。半定量组织学方法显示细胞周围胶原和整体病变有显著增加，而形态测量法显示细胞周围、静脉周围和汇管区胶原均有显著增加。两种方法之间存在显著相关性，但形态测量法具有客观性和高效性的优势。胶原增加与甲氨蝶呤累积剂量之间无相关性，这表明除甲氨蝶呤外的其他因素可能导致肝损伤。
