Markou Athanasios L P, van der Windt Armand, van Swieten Henri A, Noyez Luc
Heart Center, Radboud University Nijmegen, Department of Cardio-Thoracic Surgery, Nijmegen, The Netherlands.
Eur J Cardiothorac Surg. 2008 Nov;34(5):1009-15. doi: 10.1016/j.ejcts.2008.08.003. Epub 2008 Sep 7.
This study investigates changes of quality of life (QOL), physical activity (PA) and symptomatic status (NYHA) at one-year post-coronary artery bypass grafting (CABG).
Of 568 patients undergoing a primary isolated CABG for stable angina (NYHA <IV) pre- and 1-year postoperative data on QOL, PA, and NYHA were complete. Studied outcomes were changes in QOL, EuroQoL questionnaire, PA, the Corpus Christi Heart Project criteria and NYHA. Analysis was based on three age groups. Group A, age <65 years: 285 patients, group B, 65-74 years: 210 patients, and group C, age >or=75 years: 73 patients.
There is a similar, significant decrease of NYHA class (1.4) for the three groups (p<0.0005). An overall significant improvement for QOL and PA is however different in the three subgroups. PA improvement is not significant in group C (p=0.74), significant in group B (p=0.005) and in group A (p<0.0005). For the QOL, group A shows a significant improvement for the five different domains, group B for two, and group C only for one domain. The visual analogue score as part of the QOL registration shows a significant increase for the three groups, however the improvement is minor with age, and between A (14.6) and C (9.1) this improvement is significantly different (p=0.047).
Elderly patients have the same improvement of their symptomatic status as younger patients. However despite this improvement they have less benefit from CABG regarding to their quality of life and physical activity.
本研究调查冠状动脉旁路移植术(CABG)后一年生活质量(QOL)、身体活动(PA)及症状状态(纽约心脏协会分级,NYHA)的变化。
568例因稳定型心绞痛(NYHA<IV级)接受初次单纯CABG手术的患者,术前及术后1年的QOL、PA和NYHA数据完整。研究结果包括QOL、欧洲生活质量调查问卷、PA、科珀斯克里斯蒂心脏项目标准及NYHA的变化。分析基于三个年龄组。A组,年龄<65岁:285例患者;B组,65 - 74岁:210例患者;C组,年龄≥75岁:73例患者。
三组患者的NYHA分级均有相似且显著的降低(降低1.4级)(p<0.0005)。然而,三个亚组在QOL和PA的总体显著改善方面存在差异。C组的PA改善不显著(p = 0.74),B组显著(p = 0.005),A组极显著(p<0.0005)。对于QOL,A组在五个不同领域有显著改善,B组在两个领域有改善,C组仅在一个领域有改善。作为QOL记录一部分的视觉模拟评分显示三组均有显著提高,但改善程度随年龄增长而减小,A组(14.6)和C组(9.1)之间的改善差异显著(p = 0.047)。
老年患者与年轻患者的症状状态改善程度相同。然而,尽管有这种改善,但在生活质量和身体活动方面,他们从CABG中获得的益处较少。