STAT92E是果蝇凋亡抑制因子1（DIAP/1）的正向调节因子，可保护细胞免受辐射诱导的凋亡。
STAT92E is a positive regulator of Drosophila inhibitor of apoptosis 1 (DIAP/1) and protects against radiation-induced apoptosis.
作者信息
Betz Aurel, Ryoo Hyung Don, Steller Hermann, Darnell James E
机构信息
Laboratory of Molecular Cell Biology, The Rockefeller University, 1230 York Ave, New York, NY 10065, USA.
出版信息
Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13805-10. doi: 10.1073/pnas.0806291105. Epub 2008 Sep 8.
Abstract
The proapoptotic factors Reaper, Hid, Grim, and Sickle regulate apoptosis in Drosophila by inhibiting the antiapoptotic factor DIAP1 (Drosophila inhibitor of apoptosis 1). Heat, UV light, x-rays, and developmental signals can all increase the proapoptotic factors, but the control of transcription of the diap1 gene is unclear. We show that in imaginal discs the single Drosophila STAT protein (STAT92E) when activated can directly increase DIAP1 through binding to STAT DNA-binding sites in the diap1 promoter. The STAT92E contribution to DIAP1 production is required for cell survival after x-irradiation but not under unstressed conditions. Because DIAP1 prevents apoptosis after a variety of stresses, STAT92E may have a role in regulating stress responses in general.
摘要
促凋亡因子Reaper、Hid、Grim和Sickle通过抑制抗凋亡因子DIAP1（果蝇凋亡抑制因子1）来调节果蝇的细胞凋亡。热、紫外线、X射线和发育信号均可增加促凋亡因子，但diap1基因转录的调控尚不清楚。我们发现，在成虫盘（imaginal discs）中，单个果蝇信号转导和转录激活因子（STAT）蛋白（STAT92E）激活后可通过结合diap1启动子中的STAT DNA结合位点直接增加DIAP1的表达。STAT92E对DIAP1产生的作用在X射线照射后对细胞存活是必需的，但在无应激条件下并非如此。由于DIAP1可在多种应激后防止细胞凋亡，STAT92E可能总体上在调节应激反应中发挥作用。
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